Property Summary

NCBI Gene PubMed Count 26
PubMed Score 138.24
PubTator Score 77.98

Knowledge Summary


No data available


  Differential Expression (4)

Disease log2 FC p
osteosarcoma -2.774 8.0e-10
atypical teratoid / rhabdoid tumor -1.200 6.2e-07
glioblastoma -1.300 2.3e-05
medulloblastoma -1.200 7.0e-06

Protein-protein Interaction (4)

Gene RIF (12)

25482028 These results indicate that Smad4 acts as a tumor suppressor by activating FOXH1, and then suppressing the expression of estrogen receptor, in addition to tumor migration and invasion.
21828274 HEB and E2A-bind the SCA motif at regions overlapping SMAD2/3 and FOXH1
20634891 Observational study of gene-disease association. (HuGE Navigator)
19711044 Results suggest that PKA can negatively regulate ERalpha, at least in part, through FoxH1.
19525021 Four genetic variants are found in FOXH1 that are associated with ventricular septal defects in Chinese patients.
19525021 Observational study of gene-disease association. (HuGE Navigator)
19420158 HIV-1 Tat enhances binding of SMAD2, -3 and -4 and their binding partner Fast1 to the JCV DNA control region (CR) to stimulate JCV gene transcription in living cells
18538293 Reduced NODAL signaling via mutation of several pathway members including FOXH1 is linked to heart defects and holoprosencephaly.
16120611 FoxH1 has a role in androgen receptor-mediated transactivation
15982639 These results demonstrate for a functional role for TGF-beta ligands in regulation of mammalian Mixl1, identify FoxH1 as an essential co-activator, and implicate Nodal as the embryonic regulator of Mixl1 in mesendoderm morphogenesis.
15750622 Smad-binding peptide aptamer FOXH1 can be developed to selectively inhibit TGF-beta-induced gene expression.
15737749 This work suggests that FAST-1 may participate in the vascular smooth muscle response to injury and may represent a potential molecular target for modulating the progression of cardiac allograft vasculopathy.

AA Sequence

LAAPGPGWLLSWCSL                                                           351 - 365

Text Mined References (25)

PMID Year Title
25482028 2015 Smad4 suppresses the progression of renal cell carcinoma via the activation of forkhead box protein H1.
25201988 2014 Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
21828274 2011 HEB and E2A function as SMAD/FOXH1 cofactors.
20634891 2010 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
19711044 2009 PKA-mediated stabilization of FoxH1 negatively regulates ERalpha activity.
19525021 2010 Forkhead box H1 (FOXH1) sequence variants in ventricular septal defect.
18922797 2008 Oct25 represses transcription of nodal/activin target genes by interaction with signal transducers during Xenopus gastrulation.
18538293 2008 Reduced NODAL signaling strength via mutation of several pathway members including FOXH1 is linked to human heart defects and holoprosencephaly.
17507406 2007 Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo.
17474147 2007 Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
17438144 2007 Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation.
16120611 2005 Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor.
15982639 2005 Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1.
15750622 2005 Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP.
15737749 2005 Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells.
15363409 2004 Foxh1 is essential for development of the anterior heart field.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12471260 2002 Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1.
11371641 2001 c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity.
11076863 2000 DNA cloning using in vitro site-specific recombination.
10938097 2000 BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners.
9858566 1999 FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals.
9702198 1998 Characterization of human FAST-1, a TGF beta and activin signal transducer.
9389648 1997 Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.
9288972 1997 Smad4 and FAST-1 in the assembly of activin-responsive factor.