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  5. Fos-related antigen 2

Tbio Fos-related antigen 2

Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]

 Comments

Property Summary

NCBI Gene PubMed Count 42
PubMed Score 129.55
PubTator Score 59.57

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (6)

Disease Target Count
Juvenile arthritis 126
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.6
Disease Target Count Z-score Confidence
Crohn's disease 321 0.0 3.0
Type 1 diabetes mellitus 109 0.0 1.8
Disease Target Count Z-score Confidence
Systemic scleroderma 60 3.809 1.9
Cancer 2499 3.253 1.6

Expression

  Differential Expression (34)

Disease log2 FC p
glioblastoma 1.600 4.4e-03
acute quadriplegic myopathy 2.120 1.6e-10
adrenocortical carcinoma -1.028 7.0e-05
aldosterone-producing adenoma -1.387 4.6e-02
astrocytic glioma -2.100 1.9e-02
Astrocytoma, Pilocytic -1.100 3.6e-02
atypical teratoid / rhabdoid tumor 1.200 3.7e-02
chronic lymphosyte leukemia -1.100 9.3e-09
chronic rhinosinusitis -1.342 2.8e-02
ependymoma -1.300 4.1e-03
gastric cancer -1.100 2.3e-02
hepatocellular carcinoma -1.600 2.6e-05
interstitial cystitis -1.200 1.5e-03
intraductal papillary-mucinous adenoma (... 1.600 2.0e-03
intraductal papillary-mucinous carcinoma... 1.300 4.6e-03
juvenile dermatomyositis 1.020 3.5e-08
lung cancer -3.500 1.0e-04
lung carcinoma -1.800 7.7e-13
malignant mesothelioma -1.300 1.1e-06
medulloblastoma -1.500 4.9e-03
medulloblastoma, large-cell -1.800 5.3e-03
non diabetic and post-ischemic heart fai... -1.100 3.9e-03
oligodendroglioma -2.400 6.5e-03
osteosarcoma 1.340 5.1e-03
ovarian cancer 2.800 1.0e-05
pancreatic cancer -1.100 2.4e-03
pancreatic carcinoma -1.100 2.4e-03
pancreatic ductal adenocarcinoma liver m... 1.075 3.2e-02
pediatric high grade glioma 1.100 1.3e-02
pituitary cancer -2.700 1.3e-04
primitive neuroectodermal tumor -1.700 2.3e-03
psoriasis -1.200 1.1e-05
spina bifida -2.083 4.3e-02
tuberculosis -1.200 7.4e-04

Synonym

Accession P15408 B2RD58 B3KP27 B4DYV4 Q6FG46 FRA-2
Symbols FRA2

Gene

FOSL2

PANTHER Protein Class (2)

  Ortholog (12)

Species Source Disease
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (11)

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 GO Function (4)

 GO Component (2)

 GO Process (5)

 Compartment GO Term (18)

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 MGI Phenotype (8)

 GWAS Trait (4)

 HCA RNA Cell Line (56)

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Pathway (9)

Protein-protein Interaction (31)

ATF2   ATF7   CREB5   JUN   JUND   SORL1   ZZEF1   CARM1   CALCOCO1   VARS   HECTD3   ANKHD1   ANKRD17   IRF2BP2   CYTH2   CYTH3   COP1   KBTBD7   TSR3   NBEA   FBXO11   BACH2   YEATS4   STK40   USF2   RUFY1   IRF2BP1   DET1   TRIB1   IRF2BPL   BAHCC1  

Gene RIF (19)

AA Sequence 

MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQKFRVDMPGSGSAFIPTINAITTSQDLQWMVQPTVIT      1 - 70
SMSNPYPRSHPYSPLPGLASVPGHMALPRPGVIKTIGTTVGRRRRDEQLSPEEEEKRRIRRERNKLAAAK     71 - 140
CRNRRRELTEKLQAETEELEEEKSGLQKEIAELQKEKEKLEFMLVAHGPVCKISPEERRSPPAPGLQPMR    141 - 210
SGGGSVGAVVVKQEPLEEDSPSSSSAGLDKAQRSVIKPISIAGGFYGEEPLHTPIVVTSTPAVTPGTSNL    211 - 280
VFTYPSVLEQESPASPSESCSKAHRRSSSSGDQSSDSLNSPTLLAL                            281 - 326
//

Text Mined References (54)

PMID Year Title