Tdark FNBP4 Formin-binding protein 4

Protein Summary

Description

This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle formation. Naturally occurring mutations in this gene are associated with Waardenburg anophthalmia syndrome. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q8N3X1
• Q9H985
• Q9NT81
• Q9Y2L7

Gene Name

• FNBP4

Ensembl ID

• ENST00000263773
• ENSP00000263773
• ENSG00000109920
• ENST00000646180
• ENSP00000494562
• ENSG00000285182

Symbol

• FBP30
• KIAA1014
• FBP30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	0.98
drug perturbation	0.96
transcription factor binding site profile	0.93
ligand (protein) perturbation	0.83
disease perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.94   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 38   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.94   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0