Tbio FMNL2 Formin-like protein 2

Protein Summary

Description

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96PY5
• B2RZH5
• Q14CC9
• Q4ZG52
• Q8N3E0

Gene Name

• FMNL2

Ensembl ID

• ENST00000288670
• ENSP00000288670
• ENSG00000157827

Symbol

• FHOD2
• KIAA1902
• FHOD2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
transcription factor perturbation	0.91
ligand (protein) perturbation	0.83
virus perturbation	0.79
microRNA	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.23   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 94   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.23   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0