Property Summary

NCBI Gene PubMed Count 21
PubMed Score 19.73
PubTator Score 12.88

Knowledge Summary


No data available


Gene RIF (10)

24241165 Genome wide DNA methylation assessment approach identified novel biomarkers that differentiate between cervical cancer and normal samples. In the Validation cohort FKBP6 promoter methylation had 73% sensitivity and 80% specificity (AUC = 0.80).
22082156 Knockdown of FK506 binding protein 6, 36kDa (FKBP6) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N
20378615 Observational study of gene-disease association. (HuGE Navigator)
19001379 FKBP36 diminishes GAPDH activity by direct interaction and down-regulation of GAPDH
18529014 clathrin-FKBP36-Hsp72 complexes resulting from both identified interactions are bound to the matrices of clathrin-coated vesicles in spermatocytes, which indicates a possible role of FKBP36 and Hsp72 in the disassembly of clathrin coats
17307919 Observational study of gene-disease association. (HuGE Navigator)
17307919 may play a role in modifying the susceptibility to idiopathic spermatogenic impairment in human; allele A of c.216C>A seems to be a protective factor for the development of male infertility
16227348 Observational study of gene-disease association. (HuGE Navigator)
15696470 278A polymorphism of FKBP6 gene was associated with idiopathic azoospermia, while C/T, 370G/A, 430G/C, 467T/C, 468G/A polymorphisms might be very rare in Chinese population.
15696470 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence


Text Mined References (23)

PMID Year Title
26567527 2015 Involvement of FKBP6 in hepatitis C virus replication.
25416956 2014 A proteome-scale map of the human interactome network.
25036637 2014 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
24241165 2014 Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population.
22610502 2012 Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
20378615 2010 Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.
19001379 2009 FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor.
18529014 2008 FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes.
17307919 2007 Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men.
16983454 2006 Is a genetic defect in Fkbp6 a common cause of azoospermia in humans?
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16227348 2005 Mutations in the chromosome pairing gene FKBP6 are not a common cause of non-obstructive azoospermia.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15770126 2005 Autosomal dominant inheritance of Williams-Beuren syndrome in a father and son with haploinsufficiency for FKBP6.
15696470 2005 [Possible association between 278C/A single nucleotide polymorphism of FKBP6 and idiopathic azoospermia].
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12853948 2003 The DNA sequence of human chromosome 7.
12764197 2003 Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11322937 2001 Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases.
10631136 2000 A physical map, including a BAC/PAC clone contig, of the Williams-Beuren syndrome--deletion region at 7q11.23.
9782077 1998 A novel human gene FKBP6 is deleted in Williams syndrome.