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Tchem Peptidyl-prolyl cis-trans isomerase FKBP5

Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

 Comments

Property Summary

Ligand Count 17
NCBI Gene PubMed Count 218
PubMed Score 348.09
PubTator Score 220.48

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (7)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.6
Disease Target Count Z-score Confidence
Opiate dependence 29 0.0 5.0
Disease Target Count Z-score Confidence
post-traumatic stress disorder 40 6.021 3.0
Cancer 2499 3.207 1.6

Expression

  Differential Expression (33)

Disease log2 FC p
Rheumatoid arthritis 1.300 3.9e-02
Endometriosis -1.842 3.4e-03
acute quadriplegic myopathy 1.794 8.8e-05
adult high grade glioma 1.200 5.7e-03
astrocytoma 1.700 3.2e-10
Astrocytoma, Pilocytic 1.400 5.8e-03
atypical teratoid / rhabdoid tumor 1.300 4.9e-03
autosomal dominant Emery-Dreifuss muscul... -1.280 1.0e-02
chronic rhinosinusitis -1.441 3.4e-02
cystic fibrosis and chronic rhinosinusit... -2.071 9.5e-03
Duchenne muscular dystrophy -1.499 3.0e-07
gastric cancer 1.200 1.6e-03
glioblastoma 1.300 1.0e-04
group 3 medulloblastoma 1.300 8.2e-04
hepatocellular carcinoma 1.100 5.0e-05
Hydrolethalus syndrome -1.578 4.9e-02
interstitial cystitis 1.300 4.8e-02
intraductal papillary-mucinous adenoma (... -1.500 1.4e-03
intraductal papillary-mucinous carcinoma... -1.700 5.6e-04
intraductal papillary-mucinous neoplasm ... -1.800 1.8e-03
lung adenocarcinoma -1.100 6.3e-04
lung cancer -1.100 3.2e-02
medulloblastoma, large-cell 2.500 2.4e-03
non primary Sjogren syndrome sicca 1.600 1.9e-02
ovarian cancer -2.300 4.4e-05
pancreatic cancer 1.500 4.2e-04
pancreatic carcinoma 1.500 4.2e-04
pancreatic ductal adenocarcinoma liver m... -2.873 5.1e-03
Pick disease 1.100 4.4e-02
posterior fossa group B ependymoma 1.100 7.0e-04
psoriasis -1.700 7.0e-03
severe asthma 1.100 1.9e-07
tuberculosis and treatment for 6 months -1.200 1.1e-02

Synonym

Accession Q13451 F5H7R1 Q59EB8 Q5TGM6 PPIase FKBP5
Symbols P54
AIG6
FKBP51
FKBP54
PPIase
Ptg-10

Gene

FKBP5

PANTHER Protein Class (1)

PDB

1KT0   3O5D   3O5E   3O5F   3O5G   3O5I   3O5J   3O5K   3O5L   3O5M   3O5O   3O5P   3O5Q   3O5R   4DRH   4DRI   4DRK   4DRM   4DRN   4DRO   4DRP   4DRQ   4JFI   4JFJ   4JFK   4JFL   4JFM   4R0X   4TW6   4TW7   4TX0   4W9O   4W9P   4W9Q   5BXJ   5DIT   5DIU   5DIV   5NJX   5OMP  

  Ortholog (1)

Species Source Disease
Mouse OMA Inparanoid

 UniProt Keyword (13)

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 GO Function (3)

 GO Component (5)

 GO Process (2)

 Compartment GO Term (21)

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 IMPC Phenotype (5)

 MGI Phenotype (5)

 GWAS Trait (4)

 HCA RNA Cell Line (56)

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Pathway (11)

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Drug (2)

Structure of tacrolimus

tacrolimus
pKi 7.10

Structure of sirolimus

sirolimus
pKi 8.52

Ligand (13)

Structure of CHEMBL2348599

CHEMBL2348599
pKi 6.00

Structure of CHEMBL3794209

CHEMBL3794209
pKi 6.10

Structure of CHEMBL3623623

CHEMBL3623623
pKi 6.16

Structure of CHEMBL3623615

CHEMBL3623615
pKi 6.22

Structure of CHEMBL2058794

CHEMBL2058794
pIC50 6.34

Structure of CHEMBL2348594

CHEMBL2348594
pKd 6.44

Structure of CHEMBL2348603

CHEMBL2348603
pKi 6.70

Structure of CHEMBL3623614

CHEMBL3623614
pKi 6.80

Structure of CHEMBL3793603

CHEMBL3793603
pKi 6.85

Structure of CHEMBL3623613

CHEMBL3623613
pKi 6.96

Structure of CHEMBL3792975

CHEMBL3792975
pKi 7.37

Structure of CHEMBL3623630

CHEMBL3623630
pKi 8.22

Structure of CHEMBL3623612

CHEMBL3623612
pKi 8.40

Gene RIF (199)

AA Sequence 

MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSS      1 - 70
HDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGE     71 - 140
DLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQ    141 - 210
REEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFK    211 - 280
GGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSAN    281 - 350
EKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQD    351 - 420
AKEEANKAMGKKTSEGVTNEKGTDSQAMEEEKPEGHV                                     421 - 457
//

Text Mined References (229)

PMID Year Title