Tchem | Peptidyl-prolyl cis-trans isomerase FKBP5 |
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Comments
Property Summary
Ligand Count | 17 |
NCBI Gene PubMed Count | 218 |
PubMed Score | 348.09 |
PubTator Score | 220.48 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Arthritis, Rheumatoid | 174 | 0.0 | 0.0 |
Depressive Disorder, Major | 19 | 0.0 | 0.0 |
Endometriosis | 540 | 0.0 | 0.00336459727915343 |
Infant, Newborn, Diseases | 1 | 0.0 | 0.0 |
Neurobehavioral Manifestations | 9 | 0.0 | 0.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Opiate dependence | 29 | 0.0 | 5.0 |
Accession | Q13451 F5H7R1 Q59EB8 Q5TGM6 PPIase FKBP5 |
Symbols |
P54 AIG6 FKBP51 FKBP54 PPIase Ptg-10 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA |
CHEMBL2348599
pKi 6.00
CHEMBL3794209
pKi 6.10
CHEMBL3623623
pKi 6.16
CHEMBL3623615
pKi 6.22
CHEMBL2058794
pIC50 6.34
CHEMBL2348594
pKd 6.44
CHEMBL2348603
pKi 6.70
CHEMBL3623614
pKi 6.80
CHEMBL3793603
pKi 6.85
CHEMBL3623613
pKi 6.96
CHEMBL3792975
pKi 7.37
CHEMBL3623630
pKi 8.22
CHEMBL3623612
pKi 8.40
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSS 1 - 70 HDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGE 71 - 140 DLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQ 141 - 210 REEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFK 211 - 280 GGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSAN 281 - 350 EKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQD 351 - 420 AKEEANKAMGKKTSEGVTNEKGTDSQAMEEEKPEGHV 421 - 457 //