Property Summary

NCBI Gene PubMed Count 424
PubMed Score 1194.22
PubTator Score 907.60

Knowledge Summary

Patent (194,124)

TINX Plot

  Disease Sources (7)

Disease Target Count P-value
breast carcinoma 1614 1.66702759880315E-20
atypical teratoid / rhabdoid tumor 4369 4.6670972742718E-7
osteosarcoma 7933 1.38154502114402E-6
intraductal papillary-mucinous adenoma (IPMA) 2956 1.73283254627492E-6
Pick disease 1893 1.84604682910436E-6
intraductal papillary-mucinous carcinoma (IPMC) 2988 3.74793242597018E-6
tuberculosis 1563 5.65486307683462E-6
adrenocortical carcinoma 1427 1.24583145063789E-5
ovarian cancer 8492 8.94773008685809E-5
intraductal papillary-mucinous neoplasm (IPMN) 3289 2.004884488856E-4
glioblastoma 5572 5.92025608748238E-4
lung cancer 4473 0.00108191523702022
inflammatory breast cancer 404 0.00269902195455397
ductal carcinoma in situ 1745 0.0027522373567795
invasive ductal carcinoma 2950 0.00512776954317734
oligodendroglioma 2849 0.00525817438038082
ependymoma 2514 0.00735648659802565
gastric carcinoma 832 0.0113477703280376
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0182010368968429
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0

Expression

Synonym

Accession P11362 A8K6T9 A8K8V5 C1KBH8 P17049 Q02063 Q02065 Q14306 Q14307 Q53H63 Q59H40 Q5BJG2 Q8N685 Q9UD50 Q9UDF0 Q9UDF1 Q9UDF2 FGFR-1
Symbols CEK
FLG
HH2
OGD
ECCL
FLT2
KAL2
BFGFR
CD331
FGFBR
FLT-2
HBGFR
N-SAM
FGFR-1
HRTFDS
bFGF-R-1

Gene

PDB

1XR0   1CVS   1FQ9   1AGW   1EVT   1FGI   1FGK   2CR3   2FGI   3C4F   3DPK   3GQI   3GQL   3JS2   3KRJ   3KRL   3KXX   3KY2   3OJV   3RHX   3TT0   4F63   4F64   4F65   4NK9   4NKA   4NKS   4RWI   4RWJ   4RWK   4RWL   4UWB   4UWC   4UWY   4V01   4V04   4V05   4WUN   4ZSA   5A46   5A4C   5AM6   5AM7   5B7V   5EW8   5FLF  

  Ortholog (10)

  TechDev Info (1)

Gary Johnson Kinome profile via MIB/MS Technology

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448

Gene RIF (326)

PMID Text
26942290 We identified two recurrent mutations in FGFR1 in individuals with encephalocraniocutaneous lipomatosis, a rare neurocutaneous disorder.
26910679 FGFR1 gene mutation may play a role in the development of craniosynostosis.
26801869 FGFR1 protein expression may be a biomarker of ER-positive/HER2-negative primary breast cancer with possible resistance to standard treatment, and may be a useful tool to identify more specific patients who would benefit from FGFR-1 targeted therapy.
26788508 This meta-analysis strongly suggests that FGFR1 amplification occurs more frequently in male, squamous cell lung cancer (SQCC) and smokers, and it is a risk factor for poor prognosis among Asian patients with SQCC.
26712871 Frequency of FGFR1 amplification is similar in squamous cell carcinoma of lung with and without lymph node metastases
26687682 FGFR1/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1.
26673008 High FGFR1 expression was associated with luminal A breast cancers.
26667788 In this study we report the frequency of FGFR1 and KAT6A involvement in patients with hematological malignancies and 8p11 abnormalities.
26648125 FGFR1 contributes to cell proliferation in osteosarcoma MG63 cells, and FGFR1 mediated cell proliferation may be attributed to the regulation of the cell cycle regulator, CDK1.
26617686 determined the expression rates of FGFR1, FGF2 and IP3K as a reference for Turkish patients
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AA Sequence

MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDG      1 - 70
VQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKE     71 - 140
TDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY    141 - 210
ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVY    211 - 280
SDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLS    281 - 350
HHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS    351 - 420
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFG    421 - 490
QVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVI    491 - 560
VEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVL    561 - 630
VTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP    631 - 700
YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS    701 - 770
MPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR                      771 - 822
//

Text Mined References (445)

PMID Year Title
26942290 2016 Mosaic Activating Mutations in FGFR1 Cause Encephalocraniocutaneous Lipomatosis.
26910679 2016 Mutation Screening of Candidate Genes in Patients with Nonsyndromic Sagittal Craniosynostosis.
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
26801869 2016 Fibroblast growth factor receptor-1 protein expression is associated with prognosis in estrogen receptor-positive/human epidermal growth factor receptor-2-negative primary breast cancer.
26788508 2015 The Role of FGFR1 Gene Amplification as a Poor Prognostic Factor in Squamous Cell Lung Cancer: A Meta-Analysis of Published Data.
26712871 2016 FGFR1 Amplification in Squamous Cell Carcinoma of the Lung with Correlation of Primary and Metastatic Tumor Status.
26687682 2016 Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C?.
26673008 2016 FGFR1 is an adverse outcome indicator for luminal A breast cancers.
26667788 2016 FGFR1 and KAT6A rearrangements in patients with hematological malignancies and chromosome 8p11 abnormalities: biological and clinical features.
26648125 2016 Fibroblast growth factor receptor 1 promotes MG63 cell proliferation and is associated with increased expression of cyclin-dependent kinase 1 in osteosarcoma.
More...