Property Summary

NCBI Gene PubMed Count 424
PubMed Score 1194.22
PubTator Score 907.60

Knowledge Summary

Patent (194,124)

TINX Plot

  Disease (7)

Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0

Expression

  Differential Expression (21)

Disease log2 FC p
astrocytoma 1.900 1.6e-02
pilocytic astrocytoma 1.300 4.5e-05
ependymoma 1.600 7.4e-03
oligodendroglioma 1.500 5.3e-03
osteosarcoma 3.272 1.4e-06
atypical teratoid / rhabdoid tumor 2.500 4.7e-07
glioblastoma 1.400 5.9e-04
adrenocortical carcinoma 1.808 1.2e-05
tuberculosis -1.100 5.7e-06
pancreatic ductal adenocarcinoma liver m... 1.983 1.8e-02
intraductal papillary-mucinous adenoma (... -3.400 1.7e-06
intraductal papillary-mucinous carcinoma... -3.300 3.7e-06
intraductal papillary-mucinous neoplasm ... -3.300 2.0e-04
lung cancer 1.200 1.1e-03
inflammatory breast cancer -1.400 2.7e-03
breast carcinoma -1.200 1.7e-20
Pick disease 1.100 1.8e-06
gastric carcinoma 1.300 1.1e-02
ductal carcinoma in situ -1.200 2.8e-03
invasive ductal carcinoma -1.300 5.1e-03
ovarian cancer -1.700 8.9e-05

Synonym

Accession P11362 A8K6T9 A8K8V5 C1KBH8 P17049 Q02063 Q02065 Q14306 Q14307 Q53H63 Q59H40 Q5BJG2 Q8N685 Q9UD50 Q9UDF0 Q9UDF1 Q9UDF2 FGFR-1
Symbols CEK
FLG
HH2
OGD
ECCL
FLT2
KAL2
BFGFR
CD331
FGFBR
FLT-2
HBGFR
N-SAM
FGFR-1
HRTFDS
bFGF-R-1

Gene

PDB

1XR0   1CVS   1FQ9   1AGW   1EVT   1FGI   1FGK   2CR3   2FGI   3C4F   3DPK   3GQI   3GQL   3JS2   3KRJ   3KRL   3KXX   3KY2   3OJV   3RHX   3TT0   4F63   4F64   4F65   4NK9   4NKA   4NKS   4RWI   4RWJ   4RWK   4RWL   4UWB   4UWC   4UWY   4V01   4V04   4V05   4WUN   4ZSA   5A46   5A4C   5AM6   5AM7   5B7V   5EW8   5FLF  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

  TechDev Info (1)

Gary Johnson 302 Kinome profile via MIB/MS Technology

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448

Gene RIF (326)

PMID Text
26942290 We identified two recurrent mutations in FGFR1 in individuals with encephalocraniocutaneous lipomatosis, a rare neurocutaneous disorder.
26910679 FGFR1 gene mutation may play a role in the development of craniosynostosis.
26801869 FGFR1 protein expression may be a biomarker of ER-positive/HER2-negative primary breast cancer with possible resistance to standard treatment, and may be a useful tool to identify more specific patients who would benefit from FGFR-1 targeted therapy.
26788508 This meta-analysis strongly suggests that FGFR1 amplification occurs more frequently in male, squamous cell lung cancer (SQCC) and smokers, and it is a risk factor for poor prognosis among Asian patients with SQCC.
26712871 Frequency of FGFR1 amplification is similar in squamous cell carcinoma of lung with and without lymph node metastases
26687682 FGFR1/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1.
26673008 High FGFR1 expression was associated with luminal A breast cancers.
26667788 In this study we report the frequency of FGFR1 and KAT6A involvement in patients with hematological malignancies and 8p11 abnormalities.
26648125 FGFR1 contributes to cell proliferation in osteosarcoma MG63 cells, and FGFR1 mediated cell proliferation may be attributed to the regulation of the cell cycle regulator, CDK1.
26617686 determined the expression rates of FGFR1, FGF2 and IP3K as a reference for Turkish patients
26596276 Results identified a strong association between the abundance of Corynebacterium jeikeium and single nucleotide polymorphisms in the host FLG gene related to epidermal barrier function.
26555375 FGFR1 amplification occurs in a relevant subgroup of carcinomas of the esophagus and may play a particular role for development of squamous cell cancers.
26464698 We analyzed 11 cases of phosphaturic mesenchymal tumor in this study and found that 4/11 cases exhibited cytoplasmic and membranous staining with strong intensity, and 7/11 exhibited cytoplasmic dot-like staining with moderate to weak intensity.
26438159 We therefore suggest that FGFR inhibitors exert their effect by suppressing ERK signaling without feedback activation.
26362179 FGF1-FGFR1 axis promotes tongue squamous cell carcinoma metastasis through the epithelial-mesenchymal transition pathway
26351320 Data show that silencing of fibroblast growth factor receptors FGFR1 or FGFR2 overcomes resistance to the proto-oncogene proteins c-met (MET) inhibitor.
26334633 These findings suggest that enhanced integrin alphavbeta3 expression in addition to enhanced FGFR1 expression is critical for FGF1 to augment TGF-beta1-induced EMT in mammary epithelial cells.
26300540 The present report shows the molecular mechanism underlying the control of trans-phosphorylation of a critical auto-regulatory site in FGF receptors' catalytic domain.
26277103 Report novel FGFR1 mutations in Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.
26272615 homodimerization of unliganded FGFR1 is independent of its surface density
26239623 Amplification of the FGFR1 gene is a rare but noticeable event that can be found in 2% (6/293) of gastric adenocarcinoma cases and was associated with poor 10-year survival
26203596 distributed network of individual contributions from several regions of the kinase structure conspires to hinder Asp-Phe-Gly flip; most important of these is likely to reside in the alphaC-beta4 loop region
26199944 Two novel heterozygous missense mutations in FGFR1 and one novel heterozygous missense mutation in KISS1R, were identified in in Chinese Kallmann Syndrome Males with Cleft Lip/Palate.
26179511 FGFR1 may constitute a promising target for novel therapeutic approaches in Ewing sarcoma.
26096068 LMP1-mediated FGFR1 activation contributes to aerobic glycolysis and transformation of epithelial cells, thereby implicating FGF2/FGFR1 signalling activation in the EBV-driven pathogenesis of nasopharyngeal carcinoma.
26088290 FGFR1 Gene Copy Number gain was more frequently found (26.5%) than gene amplification (3.8%) and correlated with aggressive clinical behavior in consecutive Colorectal carinoma patients.
26083571 This study found that FGFR1 is altered by oncogenic mutations in a small subset (~7%) of cases that were associated with an adverse outcome in Pilocytic Astrocytomas.
26069105 Our results indicated that these five polymorphisms of fibroblast growth factor receptor genes do not play any independent roles in the tumorigenesis and progression of HBV-related HCC in Han Chinese patients.
26055304 FGFR1 gene rearrangement is associated with mixed-phenotype acute leukemia.
26051373 Kallmann syndrome with FGFR1 and KAL1 mutations was detected during fetal life
26020126 FGFR1 protein expression is correlated with FGFR1 mRNA levels and FGFR1 gene copy number in small cell lung cancer.
26015511 FGFR1 mRNA or protein expression, rather than FGFR1 CNG as a predictive biomarker for the response to FGFR inhibitors in a subset of patients suffering from HNSCC.
25922075 ESyt2 and ESyt3, but not ESyt1, interact with activated FGFR1.
25909503 These results suggested that FGFR1 specifically antagonizes influenza A virus replication, probably by blocking viral entry.
25900027 Increased expression of FGFR1 (and FRS2alpha) was associated with decreased progression-free survival in metastatic renal cell carcinoma.
25868865 FGFR1 expression in TNBCs is independently prognostic of OS, and H-score of 100 or more FGFR1 immunostaining may define tumors that have treatment potential via FGFR signaling inhibition.
25819384 Our results imply that FGFR1 may be a potential therapeutic target in SCLC and it could be confirmed in a clinical trial.
25760602 The 1.65 A resolution crystal structure of AZD4547 bound to the kinase domain of FGFR1 has been determined and reveals extensive drug-protein interactions
25752607 Membrane FGFR and intranucelar FGFR/CBP pathways regulate FGF-23 transcription.
25738174 RUNX2 signaling pathways with their partners TCF7 and FGFR1/2 may not be involved in CCD pathogenesis
25691251 Phosphorylation of FGFR-1, AKT, and ERK1/2 in xenograft specimens was also inhibited by AZD-4547 administration
25566961 We found that only inhibition of JNK significantly decreased the activation of MMP26 in response to FGF1 stimulation, suggesting that activation of FGFR1 signaling may activate JNK to activate MMP26 in non-small-cell lung cancer
25537505 Data show that high fibroblast growth factor receptor 1 (FGFR1) amplification had significantly shorter disease-free survival and overall survival than low/no amplification group.
25512530 approach identified 18 kinase and kinase-related genes whose overexpression can substitute for EGFR in EGFR-dependent PC9 cells, and these genes include seven of nine Src family kinase genes, FGFR1, FGFR2, ITK, NTRK1, NTRK2, MOS, MST1R, and RAF1.
25500535 FGFR1 was found commonly overexpressed in ectopic endometrium of endometriosis compared with either its eutopic counterpart or endometrium from normal patients
25485703 5-HT1A autoreceptors are recruited into a FGFR1-5-HT1A heteroreceptor complex in the midbrain raphe 5-HT nerve cells and may develop a novel function: a trophic role in midbrain 5-HT neuron systems originating from the dorsal and medianus raphe nuclei
25433983 Gender, stage, differentiation, ethnicities and test methods have no influence on FGFR1 amplification. FGFR1 amplification trends to correlate with lymph node metastasis and smoking. Whether FGFR1 amplification has effect on survival remains controversial
25394172 Probands and available family members underwent phenotyping and screening for FGFR1 mutations.
25388665 kinetics of the interaction between serine/threonine-rich domain of thrombomodulin (rTMD23) and FGFR1 were analysed in umbilical vein endothelial cells
25349422 FIIN-2 and FIIN-3 are the first inhibitors that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors
25319834 Report FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour.
25251565 A three-generation family with five members have a heterozygous FGFR1 p.Pro252Arg mutation and variable expressivity of Pfeiffer syndrome.
25249657 Endothelial cells in human patients with chronic cardiac graft rejection lose FGFR1. FGFR1 is the key regulator of TGFbeta signaling and EndMT development.
25188816 Blockade of FGFR1 by a tyrosine kinase inhibitor impairs growth of malignant pleural mesothelioma cells in vitro and in vivo. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201404-0658OC
25186177 FGF signaling mediates a positive feedback loop between prostatce cancer cells and bone cells and that blockade of FGFR1 in osteoblasts partially mediates the antitumor activity of dovitinib.
25184702 Hearing ability was strongly associated with DNA methylation levels in the promoter regions of several genes, including TCF25, FGFR1, and POLE.
25171497 Studies indicate that the overall survival was significantly worse among patients with fibroblast growth factor receptor FGFR1 and FGFR2 gene amplification: FGFR1 (hazard risk 1.57) and FGFR2 (hazard risk 2.27).
25138167 Fluorescence in situ hybridization analysis revealed no polysomy nor an amplification of the FGFR gene copy number in any case
25086725 results suggest that FGFR1 amplification is associated with smoking history and squamous cell carcinoma histology and might indicate poor prognosis.
24966347 Autocrine signaling through FGFR1 represents a targetable therapeutic pathway in malignant pleural mesothelioma.
24925055 Our findings provide evidence for mTORC1 activation and FGFR1 overexpression in human fibrolamellar carcinoma
24898159 Concomitant FGFR3 mutations and protein overexpression indicate that FGFR3-mediated signalling in these tumours would probably be highly active.
24889687 expression appears to be associated with parathyroid carcinoma in hyperparathyroidism-jaw tumor syndrome
24888332 study reports on a novel heterozygous FGFR1 mutation in 2 siblings with Hartsfield syndrome; both parents were negative for the sequence variant in FGFR1 gene; this suggests gonadal mosaicism
24861215 FGFR1 amplification is detected in a higher proportion of patients whose tumors revealed a poor response to chemotherapy.
24853178 FGFR1 amplification is common in early-stage squamous cell carcinomas of the lung and is an independent and adverse prognostic marker.
24850843 FGFR1 tyrosine kinase fusions are associated with aggressive molecular subtype of non-small cell lung cancer.
24818995 Insulin-induced apoptotic commitment depended on the down-regulation of Erk-1, insulin growth factor-1 receptor (IGF-1R), and fibroblast growth factor receptor-1 (FGFR-1)-mediated signaling.
24806303 This study presence of FGFR1 mutations in Rosette-forming glioneuronal tumors of the fourth ventricle cases.
24776628 Case Report: mutation c. 246_247delAG (p.T82Xfs110) in heterozygosis on exon 3 of the KAL2 gene in idiopathic hypogonadotrophic hypogonadism.
24776567 FGFR1 or FGFR2 genotype did not correlate with upper extremity phenotype in Pfeiffer syndrome.
24771645 High FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies.
24736592 Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease
24736083 Amplification owing to polysomy of chromosome 8, where FGFR1 locates, was observed in small-cell lung cancer.
24732674 Mutations were found in the following genes in one or more patients with congenital hypogonadotropic hypogonadism: KAL1, FGFR1, GNRHR, and CHD7
24719266 FGFR1 lacking kinase domain inhibits canine and human sarcoma cell growth In Vitro.
24618085 Data suggest that fibroblast growth factor receptor type 1 (FGFR1) isoform expression can be used as a predictive biomarker for therapeutic application of its kinase inhibitors.
24616020 Down-regulation of miR-214 expression was correlated with increased FGFR1 expression levels, which may contribute to increased colorectal liver metastasis.
24613087 FGFR1 gene polymorphism is associated with lower rate of developing cleft palate or cleft lip in Iranian patients.
24551307 Case Report: myeloproliferative neoplasm with chromosome translocation t(8;19) involving FGFR1 gene associated with systemic mastocytosis.
24503018 Nuclear targeting of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion.
24398778 Our findings suggested that FGFR inhibition could delay breast tumor progression, impair lung metastasis and break immunosuppression by effecting on tumor microenvironment, which may provide a promising therapeutic approach for breast cancer patient.
24385678 Allele frequency analysis showed significant association between the FGFR1 rs13317 polymorphism and international prostate symptom score.
24385208 FGFR1 overexpression is associated with triple-negative breast cancer.
24357456 We further demonstrated that miR-198 directly targets fibroblast growth factor receptor 1 (FGFR1) in lung cancer cells.
24323762 Individuals with the derived allele of the rs4647905:G>C polymorphism have greater levels of head morphological integration, especially in facial structures and on the shape space where the modular portion of the covariation is explicitly removed.
24305876 FGFR1, WNT, and TGF-beta have roles in signaling of reactive stroma in aggressive prostate adenocarcinomas
24302556 Amplification of FGFR1 is one of the most frequent candidate targets in lung cancer.
24294370 Increased expression of SOX2 and FGFR1 indicate poor prognosis in small cell lung cancer patients.
24255716 Our cutpoint analysis showed a clear threshold effect for the impact of FGFR1 amplification on patients' survival, which can be used as an initial guide for patient selection in trials assessing efficacy of novel FGFR inhibitors.
24183471 high level of gene amplifications brain metastases of adenocarcinomas but not in squamous cell carcinomas of the lung
24157794 Taken together, the participation of 5-HT1A and FGFR1 homodimers and recruitment of beta-arrestin2 was demonstrated in the FGFR1-5-HT1A heteroreceptor complexes upon agonist treatments.
24141780 Activated RSK2 directly interacts with and phosphorylates FGFR1, thereby modulating receptor signaling through regulation of endocytosis.
24135816 Of 454 primary colorectal cancers, 24 displayed FGFR1 amplification. Of 99 investigated tumors, 18 revealed membranous activated pFGFR1 protein. FGFR1 mRNA levels were independent of the amplification status or pFGFR1 protein occurrence.
24077455 Fibroblast growth factor receptor 1 gene locus amplification is associated with lung squamous cell carcinoma.
24063890 Mechanistic insights into the S100B-FGF2 complex interface and cell-based assay studies involving mutants led us to conclude the novel role of S100B in FGF2 mediated FGFR1 receptor inactivation.
23962428 downregulation of miR-214 in HCC and the upregulation of its target gene FGFR-1 is associated with hepatocellular carcinoma progression
23939995 Studies demonstrate that FGFR1 signaling mediates the continuation of MSC growth and establishes a receptor target for enhancing the expansion of mesenchymal progenitors while maintaining their multilineage potential.
23939983 A significant association of haplotype GTAA in BMP4 (p = 0.01) and FGFR1 rs13317 (p = 0.005) with NU could be observed.
23913758 FGFR1 amplification was found in subsets of sinonasal squamous cell carcinoma (20%), carcinomas associated with an inverted papilloma (33%), and sinonasal undifferentiated carcinoma (5%).
23887299 In this study, we provide evidence that 5% of Small-cell lung cancer cases show targetable high-level FGFR1 amplification
23861540 Network models inferred from the data revealed a conserved set of signaling pathways and RTK-specific features that grouped the RTKs into three distinct classes: (i) an EGFR/FGFR1/c-Met class ; (ii) an IGF-1R/NTRK2 class; and (iii) a PDGFRbeta class.
23812909 Identified a novel FGFR1 mutation in six out of seven Harstfield syndrome patients.
23808822 The FGFR1-amplified pancreatic carcinoma cell line PT45P1 showed high levels of FGFR1 mRNA and protein expression.
23806793 High FGFR1 gene copy number is a common finding in SCC and LCC and is an independent favourable prognostic factor.
23777766 CNTRL and FGFR1 have roles in myeloid and lymphoid malignancies in both human and mouse models
23620752 The mRNA expressions of the proangiogenic growth factors VEGF, PDGF, bFGF and their receptors (VEGFR1, VEGFR2, PDGFRA, PDGFRB, FGFR1, FGFR2) were measured and compared in gastric ulcers of cirrhotic patients.
23619603 Our data identify fibroblast growth factor receptor 1 amplification as a frequent event in primary and metastatic head and neck squamous cell carcinoma and represents a potential biomarker for more aggressive disease.
23594707 B-lymphoblastic leukemia/lymphoma associated with t(8;13)(p11;q12)/ ZMYM2 (ZNF198)-FGFR1
23569208 KLF10 is an effective repressor of myoblast proliferation and represses FGFR1 promoter activity in these cells via an Sp1 binding site.
23564461 Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.
23563700 Growth inhibition induced by ponatinib was associated with inactivation of FGFR1 and its downstream targets.
23536707 FGF2 -FGFR1 activation through an autocrine loop is a novel mechanism of acquired resistance to EGFR-tyrosine kinase inhibitors.
23468956 data demonstrate that FGFR1 and FGFR3 have largely non-overlapping roles in regulating invasion/metastasis and proliferation in distinct "mesenchymal" and "epithelial" subsets of human BC cells
23434054 Copy number variations of the FGFR1 gene occur in a subset of OTSCC with approximately 10% of cases showing amplification of the gene. FGFR1 amplification may represent a therapeutic target in OTSCC
23401445 FGFR1 amplification is much more common in squamous cell lung cancers (21%) than in lung adenocarcinoma (3.4%). Survival of FGFR1-amplified lung cancer cell lines was additionally shown to be dependent on overexpression of the FGFR1 kinase.
23348274 In Thai Pfeiffer syndrome patients, FGFR1 mutations in exon 5 were identified.
23343422 the combination of dovitinib + NVP-BEZ235 or dovitinib + AEE788 results in strong inhibition of tumor growth and a block in metastatic spread. Only these combinations strongly down-regulate the FGFR/FRS2/Erk and PI3K/Akt/mTOR signaling pathways
23334987 The role of the FGFR/klotho-axis remains still unclear in primary hyperparathyroidism.
23296701 Upregulation of FGFR1 is associated with gastric cancer.
23276709 2 patients with congenital isolated hypogonadotropic hypogonadism were found to have mutations in FGFR1 (R254W and R254Q); both are loss-of-function mutations demonstrated by their reduced overall and cell surface expression suggesting a deleterious effect on receptor folding and stability
23243019 Data suggest for therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer.
23182986 Data indicate that FGFR1 amplification is an independent negative prognostic factor in surgically resected squamous cell carcinoma of the lung (SCCL) and is associated with cigarette smoking in a dose-dependent manner.
23171834 A novel mRNA in-frame fusion between exon 4 of the breakpoint cluster region (BCR) gene at chromosome 22q11 and exon 9 of FGFR1 gene on chromosome 8p11-12 was identified by reverse transcription polymerase chain reaction
23154548 FGFR1 amplification is associated with squamous cell carcinoma of the lung.
23154428 demonstrate skeletal phenotypic characterization of patients presenting with Kallmann syndrome and FGFR1 mutations
23082000 The incidence of FGFR1 amplification within Chinese patient non-small cell lung carcinoma tumors was 6 of 48 squamous origin and 5 of 76 adenocarcinoma.
23070782 FGFR1 polymorphisms, especially rs4647905, can have an important role in the normal human skull variation, primarily due to their influence in head length.
23029290 Fibroblast growth factor receptor 1 activation leads to induction of CX3CL1 in a tumor setting.
22989054 ErbB3 but not Fgfr1 mRNA levels are reduced in leukocytes of patients with major depressive disorders compared to healthy subjects.
22955284 Nectin-1 Ig3 induced phosphorylation of FGFR1c in the same manner as the whole nectin-1 ectodomain, and promoted survival of cerebellar granule neurons induced to undergo apoptosis.
22903848 Report recycling/degradation pathways of FRG receptor 1 in human glioma cell line.
22863309 FGFR1 is amplified during the progression of in situ to invasive breast carcinoma.
22842457 The novel findings reported in this study are expected to provide valuable clues toward a complete understanding of the other genetic diseases linked to mutations in the FGFR.
22837387 study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor genes(FGFR1 or FGFR3) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3; the FGFR-TACC fusion protein displays oncogenic activity
22791819 results of the present study suggest that MUC4 promotes invasion and metastasis by FGFR1 stabilization through the N-cadherin upregulation.
22781593 Mutations in FGFR1 gene is associated with the development of myeloid and lymphoid malignancies.
22724017 The data shows that patients with congenital hypogonadotropic hypogonadism and a splice-site mutation in FGFR1 can undergo reversal.
22701738 FGFR1 activation in urothelial carcinoma cell lines promotes epithelial-mesenchymal transition via coordinated activation of multiple signalling pathways and by promoting activation of prostaglandin synthesis.
22684217 Conclude that FGFR1 amplification is one of the most frequent therapeutically tractable genetic lesions in pulmonary carcinomas.
22673519 proteins with LRR, IG, and FNIII are candidate regulators of the FGFRs. Here we identify leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) as a regulator of the FGFRs
22665522 FGFR1 localized to the nucleus specifically in invading cells in both clinical material and a three-dimensional model of breast cancer
22648708 There were no significant associations between FGFR1 and clinicopathological parameters in lung cancer
22573348 Targeting FGFR signaling is a promising new approach to treating aggressive prostate cancer
22569333 FGFR1 initiates MAPK signaling, whereas S4-dependent FGFR1 macropinocytosis modulates the kinetics of MAPK activation
22523080 KLB and FGFR1 form a 1:1 heterocomplex independent of the galectin lattice that transitions to a 1:2 complex upon the addition of FGF21.
22514272 INFS/Nurr1 nuclear partnership provides a novel mechanism for TH gene regulation in mDA neurons and a potential therapeutic target in neurodevelopmental and neurodegenerative disorders.
22499828 FGFR1 amplification is a common genetic event occurring at a frequency of 16% in L-SCCs. Moreover, lymph node metastases derived from FGFR1-amplified L-SCCs also exhibit FGFR1 amplification.
22442730 Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.
22438050 The expression of FGFR1 in patients' biopsies may serve as a marker of response to chemoradiotherapy.
22319038 genetic association studies in 103 patients from US and UK: Mutations in FGFR1, FGF8, or PROKR2 contributed to 7.8% of patients with combined pituitary hormone deficiency or septo-optic dysplasia. Data suggest genetic overlap with Kallmann syndrome.
22248288 Deletion of the D1 and the D1-D2 linker (the D1/linker region) from FGFR1c led to beta-Klotho-independent receptor activation by FGF21, suggesting that there may be a direct interaction between FGF21 and the D1/linker region-deficient FGFR1c.
22247553 Fibronectin induces endothelial cell migration through beta1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766.
22179561 An increased FGFR1 gene copy number was found in 32 (32%) lung cancer patients
22030335 FGFR1 gene rearrangement is associated with systemic mastocytosis and myeloid/lymphoid neoplasm in blast crisis.
21969607 LDH-A is tyrosine phosphorylated and activated by FGFR1 in cancer cells.
21952621 For the first time, our gene expression profiling experiment on archival tumour materials has identified upregulated FGFR1 expression to be associated with PC progression to the CR state.
21942441 Levels of FGF2 and FGFR1 in saliva and serum from patients with salivary gland tumors were significantly higher than those from healthy control subjects suggesting their potential use as cancer biomarkers.
21885851 MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1.
21868365 inductiion of mammary tumorigenesis requires activation of the epidermal growth factor receptor
21835001 FGFR1 is the major mediator with the degenerative potential in the presence of FGF-2 in human adult articular chondrocytes
21779335 Data indicate that clathrin-mediated endocytosis is required for efficient internalization and downregulation of FGFR1 while FGFR3, however, is internalized by both clathrin-dependent and clathrin-independent mechanisms.
21765395 Nedd4-1 binds directly to and ubiquitylates activated FGFR1, by interacting primarily via its WW3 domain with a novel non-canonical sequence on FGFR1, regulating endocytosis & signalling during neuronal differentiation & embryonic development.
21739604 These results point to NCAM-mediated stimulation of FGFR as a novel mechanism underlying epithelial ovarian carcinoma malignancy and indicate that this interplay may represent a valuable therapeutic target.
21712446 Data show that the majority of TN cell lines only modest sensitive to FGFR inhibition in growth but were highly sensitive in anchorage-independent conditions.
21682876 Comprehensive mutation analysis of all 7 known KS genes (KAL1, FGFR1, FGF8, PROK2, PROKR2, CHD7, and WDR11) in 30 well-phenotyped probands revealed mutations in KAL1 (3 men) and FGFR1 (all 5 women vs. 4/25 men), but not in other genes in Finland patients.
21666749 These studies show that FGFR1 amplification is common in squamous cell lung cancer, and that FGFR1 may represent a promising therapeutic target in non-small cell lung cancer.
21666686 Case Report: identify a novel fusion partner FGFR1 for the known anchor gene FOXO1 in alveolar rhabdomyosarcoma.
21621521 homodimerization of FGFR1 appear to be a fundamental mechanism for the agonist activity of all FGF ligands at least in the case of the MAPK signaling.
21527526 FGFR1/2 are expressed by bone-derived mesenchymal stem cells in vivo and in vitro and are developmentally regulated during their differentiation.
21515689 amitriptyline-induced FGFR activation might occur by the MMP-dependent shedding of FGFR ligands, such as FGF-2, thus resulting in GDNF production
21451043 FGF signaling, through cooperation between Fgfr1 and Fgfr2 (but not Fgfr3), is required for initial generation of oligodendrocyte precursors in transgenic mouse ventral forebrain, with Fgfr1 being a stronger inducer than Fgfr2.
21430024 FGFR1 is a novel obesity gene that may promote obesity by influencing adipose tissue and the hypothalamic control of appetite.
21330321 we identified a novel CUX1-FGFR1 fusion oncogene in a patient with the 8p11 myeloproliferative syndrome and demonstrated its transforming potential in the Ba/F3 cell line.
21329481 FGFR1 is highly expressed in renal cell carcinoma patients
21160078 Focal FGFR1 amplification is common in squamous cell lung cancer and associated with tumor growth and survival, suggesting that FGFR inhibitors may be a viable therapeutic option in this cohort of patients.
21041608 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20932831 Grb14 was recruited to FGFR1 into a trimeric complex containing also phospholipase C gamma
20889570 Data suggest that an FGFR1alpha-to-FGFR1beta isoform switch and increased FGF1-induced activation of FGFR1beta may result in a proliferative advantage that plays a key role during bladder tumor progression.
20855522 Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1.
20734064 Observational study of gene-disease association. (HuGE Navigator)
20717167 Observational study of gene-disease association. (HuGE Navigator)
20686451 FGFR1 expression levels in parathyroid glands were found to be positively correlated to renal function and significantly decreased over chronic kidney disase stages.
20672350 Observational study of gene-disease association. (HuGE Navigator)
20643727 Observational study of gene-disease association. (HuGE Navigator)
20634891 Observational study of gene-disease association. (HuGE Navigator)
20606682 The bFGF-FGFR1-PI3K-Rac1 pathway in the bone microenvironment may have a significant role in the invasion and metastasis of Ewing sarcoma.
20544801 Observational study of gene-disease association. (HuGE Navigator)
20538960 Observational study of gene-disease association. (HuGE Navigator)
20536592 Dental agenesis may be a clinical feature of Kallmann syndrome caused by a mutation in the FGFR1 gene.
20421966 the phosphorylation state of FLRT1, which is itself FGFR1 dependent, may play a critical role in the potentiation of FGFR1 signalling and may also depend on a SFK-dependent phosphorylation mechanism acting via the FGFR
20389169 Based on our results, it is possible that a subtle dysfunction (expression) of the FGFR1 gene is involved in the development of the most common male reproductive tract disorder - unilateral or bilateral cryptorchidism
20389085 Role of FGFR1 mutations in Kallmann syndrome (Review)
20388777 amplified FGFR expression engages the STAT3 pathway
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20362962 Mutations of FGFR1 underlie an autosomal dominant form of Kallmann syndrome.
20179196 Data suggest that amplification and overexpression of FGFR1 may be a major contributor to poor prognosis in luminal-type breast cancers, driving anchorage-independent proliferation and endocrine therapy resistance.
20117945 Recent advances in interactions of Kallman Syndrome (KS)-associated molecules within the FGFR1 signalling complex are covered in this review, and linkage of autosomal dominant and sex-linked modes of inheritance are discussed [review]
20103604 brivanib is a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases
20068287 Decreased expression of alpha-Klotho and FGFR1c in parallel with CaR expression and parathyroid cell growth may be involved in the pathogenesis of secondary hyperparathyroidism
20036812 Studies indicate communication between tumor cells and their microenvironment is through polypeptide growth factors EGF, FGF, PDGF and receptors for these growth factors.
20024612 FGFR-1 amplification or protein overexpression in breast cancers may be an indicator for brivanib treatment, where it may have direct anti-proliferative effects in addition to its' anti-angiogenic effects.
19923290 Loss of FGFR1 signaling provides evidence that extracellular signals regulate not simply the proliferation or survival of radial glial cells, but specifically their progression to intermediate progenitor cells during neurogenesis in vivo.
19920824 Endogenous SPARC expression can be modulated by FGFR1-III isoform expression. Endogenous SPARC expression in PANC-1 cells was increased in FGFR1-IIIb over-expressing cells, but decreased in FGFR1-IIIc over-expressing cells.
19920251 Data show that oncogenic forms of fibroblast growth factor receptor type 1 inhibit the pyruvate kinase M2 (PKM2) isoform by direct phosphorylation of PKM2 tyrosine residue 105 (Y(105)).
19890272 depressed expression of the Klotho-FGFR1 complex in hyperplastic glands underlies the pathogenesis of secondary hyperparathyroidism and its resistance to extremely high FGF23 levels in uremic patients.
19822079 Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours.
19820032 Loss-of-function mutations in FGFR1 underlie 7% of normosmic idiopathic hypogonadotropic hypogonadism with different degrees of impairment in vitro.
19802384 syndecan-1 and FGF-2, but not FGFR-1 share a common transport route and co-localize with heparanase in the nucleus, and this transport is mediated by the RMKKK motif in syndecan-1
19730683 Observational study of gene-disease association. (HuGE Navigator)
19728793 The aim of this study was to investigate and compare FGFR expression in in vivo embryonic limb development and in vitro chondrogenesis of mesenchymal stem cells.
19727229 There was no association among gene FGFR1 rs13317, p. E467K, p. M369I, p. S393S and gene FGF10 rs1448037 and nonsyndromic cleft lip with or without palate in Chinese population.
19727229 Observational study of gene-disease association. (HuGE Navigator)
19696444 binding of anosmin-1 to FGFR1 and heparin can play a dual role in assembly and activity of the ternary FGFR1.FGF2.heparin complex.
19666467 a neurofascin intracellular domain activates FGFR1 for neurite outgrowth, whereas the extracellular domain functions as an additional, regulatory FGFR1 interaction domain in the course of development
19665973 Study describes the crystal structure of the activated tyrosine kinase domain of FGFR1 in complex with a phospholipase Cgamma fragment.
19663702 monoclonal antibody analysis of multiple FGFR1 isoforms, generated by alternative splicing and post-translational modifications through glycosylation
19658100 ZNF198-FGFR1 is associated with phosphorylation of several proteins including SSBP2, ABL, FLJ14235, CALM and TRIM4 proteins.
19574212 that the main role of heparin in FGF-induced signaling is to protect this naturally unstable protein against heat and/or proteolytic degradation and heparin is not essential for a direct FGF1-FGFR interaction and receptor activation
19489874 Observational study of gene-disease association. (HuGE Navigator)
19458078 FGFR1 has significant effects on urothelial cell phenotype and may represent a useful therapeutic target in some cases of urothelial carcinoma.
19453261 Observational study of gene-disease association. (HuGE Navigator)
19330026 Data show that FGFR1 and DDHD2 at 8p12 cooperated functionally with MYC, whereas CCND1 and ZNF703 cooperated with a dominant negative form of TP53.
19258500 Results show the transforming activity of FGFR1 in mammary epithelial cells and identify RSK as a critical component of FGFR1 signaling in lobular carcinomas.
19224897 sequential autophosphorylation of five tyrosines in the FGFR1 kinase domain is under kinetic control, mediated by both the amino acid sequence surrounding the tyrosines and their locations within the kinase structure
19211868 Signaling of transgenic Fgfr1 and Fgfr2 is important for their potential ability to mediate axon-glial interaction in the peripheral sensory pain pathway, via influencing myelinating and nonmyelinating Schwann cell function.
19096867 FGF-2 and FGFR1 expression is preserved in the motor system in end stage ALS.
19082464 Overexpression of the FGFR-1 gene may thus be a useful predictor of liver metastasis in patients with colorectal cancer.
18978678 Observational study of gene-disease association. (HuGE Navigator)
18940940 Fibroblast growth factor receptor 1 activity is required for FGF-1 stimulated cell proliferation and priming in early adipogenic events.
18829480 bFGF, FGFR1, and FGFR2 are frequently overexpressed in squamous cell carcinoma and adenocarcinoma of the lung and may have a role in neoplasm pathogenesis
18790757 These results indicate that EphA4 plays an important role in malignant phenotypes of glioblastoma by enhancing cell proliferation and migration through accelerating a canonical FGFR signaling pathway.
18723471 no mutations found in Kallmann syndrome
18723471 Observational study of gene-disease association. (HuGE Navigator)
18719360 Temporal-mediatd FGFR1 indepepndence: implications for targeting candidate molecules in prostate cancer are reported.
18682503 Observational study of gene-disease association. (HuGE Navigator)
18669637 the FGF binding domain and the heparin binding domain are necessary for the hBP3 interaction with endogenous FGF and the activation of FGFR signaling in vivo
18665077 FGFR1-IIIb and FGFR1-IIIc are coexpressed, and the FGFR1-III isoforms are differentially regulated by growth factors and cyclin D1.
18563556 BRCA2-associated cancers were characterized by the higher relative expression of FGF1 and FGFR2
18480409 fibroblast growth factor receptor 1 ubiquitination is required for its intracellular sorting but not for its endocytosis
18469019 Identification of two previously unreported SNPs in FGFR1 and FABP3 associated with BMD and a third SNP in TIMP2 related to risk for non-vertebral osteoporotic fractures.
18469019 Observational study of gene-disease association. (HuGE Navigator)
18463157 12% of Kallman syndrome males have KAL1 deletions, but intragenic deletions of the FGFR1, GNRH1, GNRHR, GPR54 and NELF genes are uncommon in Idiopathic hypogonadotropic hypogonadism/Kallman syndrome.
18415014 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18411303 p38alpha MAPK has a critical role in the regulated translocation of exogenous FGF1 into the cytosol/nucleus
18315732 Observational study of gene-disease association. (HuGE Navigator)
18231572 In human uterine leiomyomas, FGFR1 were also overexpressed.
18216705 No sequence variation was found, indicating that mutations in the "hot spot" exons are not associated with nonsynostotic plagiocephaly.
18216705 Observational study of genotype prevalence. (HuGE Navigator)
18171671 Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1
18160472 KAL1 mutations result in a more severe reproductive phenotype than FGFR1/KAL2 mutations.
18059337 Molecular analyses in salivary gland tumors revealed that ring formation consistently generated novel FGFR1-PLAG1 gene fusions in which the 5'-part of FGFR1 is linked to the coding sequence of PLAG1
18042549 the involvement of FGFR-1 through FGF2 in eliciting PGE(2) angiogenic responses
18034870 Current evidence supports a heparan sulphate -dependent interaction between anosmin-1 and FGFR1, where anosmin-1 serves as a co-ligand activator enhancing the signal activity. (Review)
17963255 FGF and FGFR may have a role in cleft lip and cleft palate
17893707 Observational study of gene-disease association. (HuGE Navigator)
17696196 data suggest an important role for FGFR1 and FGFR1-downstream genes in rhabdomyosarcoma (RMS) tumorigenesis and a possible association with the deregulation of proliferation and differentiation of skeletal myoblasts in RMS
17671674 analysis of EGFR, HER2 and HER3 expression in esophageal primary tumours and corresponding metastases
17545628 FGF receptor 1 (FGFR1), which is expressed mainly in neoplastic thyroid cells, propagates MAPK activation and promotes tumor progression. In contrast, FGFR2 is down-regulated in neoplastic thyroid cells through DNA promoter methylation.
17414280 no evidence that mosaicism for mutations, normally associated with syndromal forms of craniosynostosis, occur in single suture craniosynostosis
17397528 FGFR1 has a role in preventing progression of breast neoplasms
17389761 ZNF198-FGFR1 activated both the AKT and mitogen activated protein kinase (MAPK) prosurvival signaling pathways, resulting in elevated phosphorylation of the AKT target FOXO3a at T32 and BAD at S112, respectively.
17366557 results of analysis of the genome-wide scan data was a 20 cM region at 8p11-23 in which markers had LODs > or =1.0. Linkage and association analyses of these SNPs yield suggestive results for markers in FGFR1 and BAG4.
17360555 FGF3, FGF7, FGF10, FGF18, and FGFR1 may have roles in nonsyndromic cleft lip and palate
17343269 Observational study of gene-disease association. (HuGE Navigator)
17318851 Observational study of gene-disease association. (HuGE Navigator)
17318851 Data suggest that preferential premolar agenesis is associated with FGFR and IRF6.
17255109 PP2A binding to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of FGFR stimulation
17154279 Identification of 15 new FGFR1 sequence variants in 17 patients with Kallman Syndrome.
17121884 FGFR1 signaling contributes to the survival of MDA-MB-134 cells.
16949906 Immunohistochemical expression of FGFR1 in tumors was confirmed by real-time polymerase chain reaction.
16876430 Data suggest that the relative concentrations of Anosmin-1 and FGF-2 modulate the migration of oligodendrocyte precursors during development through their interaction with FGFR1.
16807244 analysis of heparan sulfate-related oligosaccharide binding to fibroblast growth factors 1 and 2 and their receptors
16807070 Analysis of FGFR1 protein revealed that a high FGFR1 gene expression is a distinct molecular feature of early OSCC indicating a participation in initial oral carcinogenesis.
16764984 Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes.
16757108 Paediatric phenotypic expression of FGFR1 loss of function mutations is highly variable, the severity of the oro-facial malformations at birth does not predict gonadotropic function at the puberty.
16685373 These results suggest that constitutive levels of both FGFR1 and FGFR3, but not FGFR4 are essential for FGF-stimulated anchorage-independent growth of SW-13 cells.
16606836 Mutations leading to FGFR1 loss-of-function were found.
16598308 The activation of FGF-2/FGFR1beta supports progression and chemoresistance in subsets of AML. Therefore, FGFR1 targeting may be of therapeutic benefit in subsets of AML.
16424058 up-regulation of the secreted FGF-BP1 protein during initiation of pancreas and colon neoplasia could make this protein a possible serum marker indicating the presence of high-risk premalignant lesions
16365308 FGF-receptor-mediated mitogen-activated protein kinase stimulation is potentiated in cells costimulated with ephrin-A1
16316338 the initial stimulus for renal inflammation, whether immune complex, hypersensitivity or rejection, did not alter expression patterns of FGF-1 or its receptor
16305343 data describe percentage of bone marrow cells expressing receptors for interleukin-1, platelet-derived growth factor, fibroblast growth factor, transforming growth factor-beta, epidermal growth factor and c-Fos and c-Myc in untreated lung & breast cancer
16188231 Stimulation of FGFR-1 results in a Ca2+ channel-independent change of gene expression in retinal pigment epithelial cells.
16186508 Two somatic mutations in kinase domain found in glioblastomas (N546K, R576W).
16091423 Data indicate that after endocytosis, fibroblast growth factor receptor (FGFR)4 and its bound ligand, FGF1, are sorted mainly to the recycling compartment, whereas FGFR1-3 with ligand are sorted mainly to degradation in the lysosomes.
15955231 involvement of a nuclear matrix bound FGFR1 in transcriptional and RNA processing events in the cell nucleus
15929978 The interaction of FGFR1 with CREB binding protein allows activation of gene transcription and may play a role in cell differentiation.
15817662 When used individually, FGFR1 partially prevented goiter and sVEGFR1 partially reduced vascular volume.
15774903 FGFR-1 is expressed in early hematopoietic/endothelial precursor cells, as well as in a subpool of endothelial cells in tumor vessels, and that it is critical for hematopoietic but not for vascular development
15680705 Fibroblast growth factor trophic signaling to differentiated neurons could involve the release of astrocytic basic FGF acting on neuronal FGFR1 expression.
15618886 In 'undifferentiated' neurospheres of embryonic brain and spinal cord, transcripts from FGFR1 and FGFR2 were consistently detected.
15613419 the reversal of hypogonadotropic hypogonadism in a proband carrying an FGFR1 mutation suggests a role of FGFR1 beyond embryonic GnRH neuron migration, and a loss of function mutation in the FGFR1 gene causing delayed puberty.
15564375 Recruitment of SRC to FRS2 leads to activation of signal attenuation pathways.
15558020 The reciprocal relationship in gene expression between FGFR1 and FGFR3 in colorectal tissue plays an important role in the progression of the carcinomas to malignancy.
15509650 conjoint endocytosis and trafficking is a novel mechanism for the coregulation of E-cadherin and FGFR1 during cell signaling and morphogenesis
15316024 insulin receptor substrate-4 and ShcA have roles in signaling by the fibroblast growth factor receptor
15297314 fibrinogen binding of FGF-2 enhances EC proliferation through the coordinated effects of colocalized alpha(v)beta(3) and FGFR1
15273729 Although FGFR-1 dimerization achieved by fgfr-2 injection led to highly differentiated and smaller bladder tumors, no sign of reduction of tumor angiogenesis was observed, thus suggesting that endothelial cells are resistant to FGF.
15117958 Results suggest that active fibroblast growth factor receptor 1 kinase regulates the functions of nuclear 90-kDa ribosomal S6 kinase.
15096041 The weak binding affinity of the fibroblast growth factor receptor (FGFR) 1 interaction with heparin suggests that in this model, FGFR and heparan sulfate proteoglycan are unbound in the absence of FGF ligand on the cell surface.
15001591 two novel intragenic FGFR1 mutations in two sporadic male cases in Kallmann syndrome
14636241 Here we show that the TCR and fibroblast growth factor receptors co-localize during combined stimulation [which] synergistically enhances the activation of nuclear factors of activated T cells.
14587039 involvement of a nuclear matrix bound FGFR1 in transcriptional and RNA processing events in the cell nucleus
12799194 Tyrosine 463 is phosphorylated and able to transduce signals in response to FGF-2 treatment alone. Furthermore, FGFR-1 dimerization/kinase activation is stabilized by heparin.
12794748 HFGFR1 was expressed primarily in the ventricular zone embryologically
12791257 Results describe a direct interaction between neural cell adhesion molecule (fibronectin type III [F3] modules 1 and 2) and fibroblast growth factor receptor R1 (Ig modules 2 and 3) by surface plasmon resonance analysis.
12746216 TSH stimulates FGFR1 but not FGF-2 expression and PKC activation stimulates FGF-2 synthesis and secretion, and TSH synergizes with PKC activators so increases in FGFR1 or FGF-2 or in both may contribute to goitrogenesis.
12651930 expression system is involved in angiogenesis in inflamed synovial tissue in the temporomandibular joint
12627230 FGFR1 has a role in autosomal dominant Kallmann syndrome
12614330 cAMP-induced nuclear accumulation of FGFR1 provides a signal that triggers molecular events leading to neuronal differentiation of neuronal progenitor cells
12604616 FGFR1 tyrosine phosphorylation is inhibited by sef protein
12594223 ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors.
12573278 alternatively spliced FGFR-1 isoforms induce differential signal transduction pathways
12440521 Recombinant FGFR1 was expressed on the surface of Sf9 insect cells. The peptide ValTyrMetSerProPhe can specifically bind to the hydrophobic surface of FGFR1.
12411316 Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells.
12397010 Our results suggest an autocrine role of the FGF-FGFR-1 system in the pathogenesis of COPD-associated vascular remodeling.
12373339 Differences in spatial patterns of FGFR expression in normal skin may generate functional diversity in response to FGFs, and in wounded skin FGFs may function in wound healing via induced FGFRs.
12141425 Review of FGFR1 isoforms and structure-activity analysis [review]
12121226 CD56 molecules on NK cells interact with fibroblast growth factor receptor 1 on Jurkat T cells to trigger IL-2 production.
12080186 Inhibiting expression of bFGF or FGFR-1 in only the melanoma cells is as effective in blocking tumor growth as simultaneously inhibiting bFGF or FGFR-1 synthesis in the melanoma cells and the melanoma cell-interspersing vasculature.
12031912 overexpressed in acute myeloid luekemia while translocations associated with this gene are absent, and more frequently in patients with CD56 immunophenoytpe
11919391 REVIEW; The 8p11 myeloproliferative syndrome is a distinct clinical entity caused by constitutive activation of FGFR1.
11759058 distribution in normal endocrine cells and related tumors of the gastroenteropancreatic system; immunoreactive in rare duodenal endocrine cells and in pancreatic A cells
11746971 In the fusion of the FGFR1 and BCR genes in myeloproliferative disorder, it is likely that the dimerization properties of BCR lead to aberrant FGFR1 signaling and neoplastic transformation.
11693202 vitronectin increased the presence of all four growth factor receptors and most notably, VEGFR-1; in contrast, fibrin decreased all four receptors, especially FGFR-1 and FGFR-2

AA Sequence

MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDG      1 - 70
VQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKE     71 - 140
TDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY    141 - 210
ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVY    211 - 280
SDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLS    281 - 350
HHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS    351 - 420
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFG    421 - 490
QVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVI    491 - 560
VEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVL    561 - 630
VTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP    631 - 700
YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS    701 - 770
MPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR                      771 - 822
//

Text Mined References (445)

PMID Year Title
26942290 2016 Mosaic Activating Mutations in FGFR1 Cause Encephalocraniocutaneous Lipomatosis.
26910679 2016 Mutation Screening of Candidate Genes in Patients with Nonsyndromic Sagittal Craniosynostosis.
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
26801869 2016 Fibroblast growth factor receptor-1 protein expression is associated with prognosis in estrogen receptor-positive/human epidermal growth factor receptor-2-negative primary breast cancer.
26788508 2015 The Role of FGFR1 Gene Amplification as a Poor Prognostic Factor in Squamous Cell Lung Cancer: A Meta-Analysis of Published Data.
26712871 2016 FGFR1 Amplification in Squamous Cell Carcinoma of the Lung with Correlation of Primary and Metastatic Tumor Status.
26687682 2016 Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C?.
26673008 2016 FGFR1 is an adverse outcome indicator for luminal A breast cancers.
26667788 2016 FGFR1 and KAT6A rearrangements in patients with hematological malignancies and chromosome 8p11 abnormalities: biological and clinical features.
26648125 2016 Fibroblast growth factor receptor 1 promotes MG63 cell proliferation and is associated with increased expression of cyclin-dependent kinase 1 in osteosarcoma.
26617686 2015 Expression of fibroblast growth factor receptor 1, fibroblast growth factor 2, phosphatidyl inositol 3 phosphate kinase and their clinical and prognostic significance in early and advanced stage of squamous cell carcinoma of the lung.
26596276 2015 Genetic associations and shared environmental effects on the skin microbiome of Korean twins.
26555375 2015 FGFR1 Amplification Is Often Homogeneous and Strongly Linked to the Squamous Cell Carcinoma Subtype in Esophageal Carcinoma.
26464698 2015 Fibroblast growth factor receptor 1 (FGFR1) expression in phosphaturic mesenchymal tumors.
26438159 2015 ERK Signal Suppression and Sensitivity to CH5183284/Debio 1347, a Selective FGFR Inhibitor.
26362179 2015 FGF1-FGFR1 axis promotes tongue squamous cell carcinoma (TSCC) metastasis through epithelial-mesenchymal transition (EMT).
26351320 2015 Targeting FGFR Pathway in Human Hepatocellular Carcinoma: Expressing pFGFR and pMET for Antitumor Activity.
26334633 2015 Enhanced Expression of Integrin ?v?3 Induced by TGF-? Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-?-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells.
26300540 2015 Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain.
26277103 2015 Novel FGFR1 mutations in Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism: evidence for the involvement of an alternatively spliced isoform.
26272615 2015 Unliganded fibroblast growth factor receptor 1 forms density-independent dimers.
26267536 2015 Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy.
26239623 2015 Fibroblast growth factor receptor 1 gene amplification in gastric adenocarcinoma.
26203596 2015 Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase.
26199944 2015 Novel FGFR1 and KISS1R Mutations in Chinese Kallmann Syndrome Males with Cleft Lip/Palate.
26179511 2015 Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma.
26096068 2015 Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells.
26088290 2015 Fibroblast Growth Factor Receptor 1 Gene Copy Number and mRNA Expression in Primary Colorectal Cancer and Its Clinicopathologic Correlation.
26083571 2015 KIAA1549: BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic Astrocytomas.
26069105 2015 Polymorphisms of FGFR1 in HBV-related hepatocellular carcinoma.
26055304 2016 Clinical activity of ponatinib in a patient with FGFR1-rearranged mixed-phenotype acute leukemia.
26051373 2015 Kallmann syndrome with FGFR1 and KAL1 mutations detected during fetal life.
26020126 2015 Fibroblast Growth Factor Receptor 1 and Related Ligands in Small-Cell Lung Cancer.
26015511 2015 FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers.
25922075 2015 Extended Synaptotagmin Interaction with the Fibroblast Growth Factor Receptor Depends on Receptor Conformation, Not Catalytic Activity.
25909503 2015 A Functional Role of Fibroblast Growth Factor Receptor 1 (FGFR1) in the Suppression of Influenza A Virus Replication.
25900027 2015 The impact of FGFR1 and FRS2? expression on sorafenib treatment in metastatic renal cell carcinoma.
25868865 2015 Expression of FGFR1 is an independent prognostic factor in triple-negative breast cancer.
25819384 2015 The frequency and impact of FGFR1 amplification on clinical outcomes in Korean patients with small cell lung cancer.
25760602 2015 The 1.65?Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition.
25752607 2015 Membrane and integrative nuclear fibroblastic growth factor receptor (FGFR) regulation of FGF-23.
25738174 2015 Expression of RUNX2 and its signaling partners TCF7, FGFR1/2 in cleidocranial dysplasia.
25691251 2015 AZD-4547 exerts potent cytostatic and cytotoxic activities against fibroblast growth factor receptor (FGFR)-expressing colorectal cancer cells.
25566961 2015 Activation of FGF receptor signaling promotes invasion of non-small-cell lung cancer.
25537505 2015 Fibroblast growth factor receptor 1 gene amplification is associated with poor survival in patients with resected esophageal squamous cell carcinoma.
25512530 2014 Genetic modifiers of EGFR dependence in non-small cell lung cancer.
25500535 2015 Increased expression of fibroblast growth factor receptor 1 in endometriosis and its correlation with endometriosis-related dysmenorrhea and recurrence.
25485703 2015 Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system.
25433983 2015 FGFR1 amplification in lung squamous cell carcinoma: a systematic review with meta-analysis.
25394172 2015 Congenital hypogonadotropic hypogonadism with split hand/foot malformation: a clinical entity with a high frequency of FGFR1 mutations.
25388665 2015 FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis.
25349422 2014 Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
25319834 2015 Identification of a novel FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour.
25251565 2014 Variable expressivity of pfeiffer syndrome in a family with FGFR1 p.Pro252Arg mutation.
25249657 2014 Fibroblast growth factor receptor 1 is a key inhibitor of TGF? signaling in the endothelium.
25241761 2014 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
25188816 2014 Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy.
25186177 2014 Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases.
25184702 2014 Epigenome-wide DNA methylation in hearing ability: new mechanisms for an old problem.
25171497 2014 Prognostic value of FGFR gene amplification in patients with different types of cancer: a systematic review and meta-analysis.
25138167 2014 Absence of amplification of the FGFR1-gene in human malignant mesothelioma of the pleura: a pilot study.
25086725 2014 FGFR1 amplification is associated with poor prognosis and smoking in non-small-cell lung cancer.
25077900 2014 The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients.
24966347 2014 Nonamplified FGFR1 is a growth driver in malignant pleural mesothelioma.
24925055 2015 mTORC1 and FGFR1 signaling in fibrolamellar hepatocellular carcinoma.
24898159 2015 Fibroblast growth factor receptor (FGFR) gene amplifications are rare events in bladder cancer.
24889687 2014 Upregulation of FGFR1 expression is associated with parathyroid carcinogenesis in HPT-JT syndrome due to an HRPT2 splicing mutation.
24888332 2014 Novel de novo heterozygous FGFR1 mutation in two siblings with Hartsfield syndrome: a case of gonadal mosaicism.
24861215 2014 Fibroblastic growth factor receptor 1 amplification in osteosarcoma is associated with poor response to neo-adjuvant chemotherapy.
24853178 2014 Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer.
24850843 2014 FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer.
24818995 2014 High insulin-induced down-regulation of Erk-1/IGF-1R/FGFR-1 signaling is required for oxidative stress-mediated apoptosis of adipose-derived stem cells.
24806303 2014 FGFR1 mutations in Rosette-forming glioneuronal tumors of the fourth ventricle.
24776628 Genetic diagnosis of idiopathic hypogonadotrophic hypogonadism: a new point mutation in the KAL2 gene.
24776567 2014 Upper extremity anomalies in Pfeiffer syndrome and mutational correlations.
24771645 2014 FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies.
24736592 2014 Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease.
24736083 2014 Characterization of fibroblast growth factor receptor 1 in small-cell lung cancer.
24732674 2014 Genetics of congenital hypogonadotropic hypogonadism in Denmark.
24719266 2015 Canine and human sarcomas exhibit predominant FGFR1 expression and impaired viability after inhibition of signaling.
24618085 2014 Fibroblast growth factor receptor splice variants are stable markers of oncogenic transforming growth factor ?1 signaling in metastatic breast cancers.
24616020 2014 Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression.
24613087 2014 Investigation of FGF1 and FGFR gene polymorphisms in a group of Iranian patients with nonsyndromic cleft lip with or without cleft palate.
24551307 2014 Systemic mastocytosis with associated myeloproliferative neoplasm with t(8;19)(p12;q13.1) and abnormality of FGFR1: report of a unique case.
24503018 2014 Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion.
24398778 2014 Inhibition of FGFR signaling by PD173074 improves antitumor immunity and impairs breast cancer metastasis.
24385678 2013 Involvement of fibroblast growth factor receptor genes in benign prostate hyperplasia in a Korean population.
24385208 2014 Low prognostic implication of fibroblast growth factor family activation in triple-negative breast cancer subsets.
24357456 2014 MicroRNA-198 inhibits proliferation and induces apoptosis of lung cancer cells via targeting FGFR1.
24323762 FGFR1 signaling is associated with the magnitude of morphological integration in human head shape.
24305876 2014 FGFR1-WNT-TGF-? signaling in prostate cancer mouse models recapitulates human reactive stroma.
24302556 2014 Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer.
24294370 2013 Elevated expression of SOX2 and FGFR1 in correlation with poor prognosis in patients with small cell lung cancer.
24255716 2013 Fibroblast growth factor receptor 1 amplification in non-small cell lung cancer by quantitative real-time PCR.
24183471 2014 High rate of FGFR1 amplifications in brain metastases of squamous and non-squamous lung cancer.
24157794 2013 Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of ?-arrestin2.
24141780 2014 RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789.
24135816 2013 Fibroblast growth factor receptor 1 as a putative therapy target in colorectal cancer.
24077455 2013 Prognostic value of fibroblast growth factor receptor 1 gene locus amplification in resected lung squamous cell carcinoma.
24063890 2013 Structural insights into the interaction of human S100B and basic fibroblast growth factor (FGF2): Effects on FGFR1 receptor signaling.
23962428 2013 Downregulation of microRNA-214 and overexpression of FGFR-1 contribute to hepatocellular carcinoma metastasis.
23939995 2013 FGFR1 signaling stimulates proliferation of human mesenchymal stem cells by inhibiting the cyclin-dependent kinase inhibitors p21(Waf1) and p27(Kip1).
23939983 2013 Polymorphisms in BMP4 and FGFR1 genes are associated with fracture non-union.
23913758 2014 Fibroblast growth factor receptor-1 as a potential therapeutic target in sinonasal cancer.
23887299 2014 Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer.
23861540 2013 Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks.
23812909 2013 FGFR1 mutations cause Hartsfield syndrome, the unique association of holoprosencephaly and ectrodactyly.
23808822 2013 Fibroblast growth factor receptor 1 gene amplification in pancreatic ductal adenocarcinoma.
23806793 2013 Fibroblast growth factor receptor 1 (FGFR1) copy number is an independent prognostic factor in non-small cell lung cancer.
23777766 2013 Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models.
23643382 2013 Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.
23620752 2013 The diminished expression of proangiogenic growth factors and their receptors in gastric ulcers of cirrhotic patients.
23619603 2013 Fibroblast growth factor receptor 1 amplification is a common event in squamous cell carcinoma of the head and neck.
23597563 2013 Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.
23597562 2013 Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.
23594707 2013 B-lymphoblastic leukemia/lymphoma associated with t(8;13)(p11;q12)/ ZMYM2 (ZNF198)-FGFR1 : rare case and review of the literature.
23569208 2013 Repression of myoblast proliferation and fibroblast growth factor receptor 1 promoter activity by KLF10 protein.
23564461 2013 Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.
23563700 2013 Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1.
23536707 2013 Activation of the FGF2-FGFR1 autocrine pathway: a novel mechanism of acquired resistance to gefitinib in NSCLC.
23468956 2013 Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: implications for therapeutic targeting.
23434054 2013 Frequency of fibroblast growth factor receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome.
23401445 2013 New targetable oncogenes in non-small-cell lung cancer.
23382219 2013 Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
23348274 2013 FGFR1 and FGFR2 mutations in Pfeiffer syndrome.
23343422 2013 Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models.
23334987 2013 Involvement of ?-klotho, fibroblast growth factor-, vitamin-D- and calcium-sensing receptor in 53 patients with primary hyperparathyroidism.
23296701 2013 miR-133b acts as a tumor suppressor and negatively regulates FGFR1 in gastric cancer.
23276709 2013 Comparative functional analysis of two fibroblast growth factor receptor 1 (FGFR1) mutations affecting the same residue (R254W and R254Q) in isolated hypogonadotropic hypogonadism (IHH).
23243019 2013 FGF-2 disrupts mitotic stability in prostate cancer through the intracellular trafficking protein CEP57.
23182986 2013 Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer.
23171834 2013 A case of 8p11 myeloproliferative syndrome with BCR-FGFR1 gene fusion presenting with trilineage acute leukemia/lymphoma, successfully treated by cord blood transplantation.
23154548 2012 FGFR1 amplification in squamous cell carcinoma of the lung.
23154428 2012 Evidence that FGFR1 loss-of-function mutations may cause variable skeletal malformations in patients with Kallmann syndrome.
23082000 2012 Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models.
23070782 Fibroblast growth factor receptor 1 (FGFR1) variants and craniofacial variation in Amerindians and related populations.
23029290 2012 Fibroblast growth factor receptor 1 activation in mammary tumor cells promotes macrophage recruitment in a CX3CL1-dependent manner.
22989054 2012 ErbB3 mRNA leukocyte levels as a biomarker for major depressive disorder.
22955284 2012 Nectin-1 binds and signals through the fibroblast growth factor receptor.
22927827 2012 SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.
22903848 2013 Sorting of the FGF receptor 1 in a human glioma cell line.
22863309 2012 FGFR1 is amplified during the progression of in situ to invasive breast carcinoma.
22842457 2012 Molecular basis for the Kallmann syndrome-linked fibroblast growth factor receptor mutation.
22837387 2012 Transforming fusions of FGFR and TACC genes in human glioblastoma.
22791819 2012 MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1.
22781593 2013 Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities.
22751148 2012 The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.
22724017 2012 Reversible congenital hypogonadotropic hypogonadism in patients with CHD7, FGFR1 or GNRHR mutations.
22701738 2012 FGFR1-induced epithelial to mesenchymal transition through MAPK/PLC?/COX-2-mediated mechanisms.
22684217 2012 Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer.
22673519 2012 Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1.
22665522 2012 FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior.
22648708 2012 FGFR1 expression and gene copy numbers in human lung cancer.
22573348 2012 Targeting fibroblast growth factor receptor signaling inhibits prostate cancer progression.
22569333 2012 Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis.
22523080 2012 Dynamics and Distribution of Klotho? (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex.
22514272 2012 Cooperation of nuclear fibroblast growth factor receptor 1 and Nurr1 offers new interactive mechanism in postmitotic development of mesencephalic dopaminergic neurons.
22499828 2012 Rationale for treatment of metastatic squamous cell carcinoma of the lung using fibroblast growth factor receptor inhibitors.
22442730 2012 Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.
22438050 2012 The fibroblast growth factor receptor 1 (FGFR1), a marker of response to chemoradiotherapy in breast cancer?
22319038 2012 Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia.
22248288 2012 Understanding the physical interactions in the FGF21/FGFR/?-Klotho complex: structural requirements and implications in FGF21 signaling.
22247553 2012 Fibronectin induces endothelial cell migration through ?1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766.
22235191 2012 Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal.
22179561 2012 Increased FGFR1 copy number in lung squamous cell carcinomas.
22035699 2012 Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity.
22030335 2012 Unique association of systemic mastocytosis and myeloid/lymphoid neoplasm in blast crisis with abnormality of FGFR1 gene.
21969607 2011 Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.
21952621 2011 Upregulated FGFR1 expression is associated with the transition of hormone-naive to castrate-resistant prostate cancer.
21942441 2012 The evaluation of basic fibroblast growth factor and fibroblastic growth factor receptor 1 levels in saliva and serum of patients with salivary gland tumor.
21885851 2011 MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1.
21868365 2011 Mammary tumorigenesis induced by fibroblast growth factor receptor 1 requires activation of the epidermal growth factor receptor.
21835001 2011 Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes.
21779335 2011 Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling.
21765395 2011 Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.
21739604 2011 The adhesion molecule NCAM promotes ovarian cancer progression via FGFR signalling.
21712446 2011 FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo.
21700882 2011 Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism.
21682876 2011 Incidence, phenotypic features and molecular genetics of Kallmann syndrome in Finland.
21666749 2011 Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer.
21666686 2011 FOXO1-FGFR1 fusion and amplification in a solid variant of alveolar rhabdomyosarcoma.
21621521 2011 Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family.
21527526 2011 Inhibition of cellular senescence by developmentally regulated FGF receptors in mesenchymal stem cells.
21515689 2011 Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production.
21454610 2011 A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor.
21451043 2011 Fibroblast growth factor signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrain.
21430024 2011 Genetic association and gene expression analysis identify FGFR1 as a new susceptibility gene for human obesity.
21330321 2011 The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11).
21329481 2011 Overexpression of fibroblast growth factor receptors FGFR1 and FGFR2 in renal cell carcinoma.
21160078 2010 Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.
21041608 2011 Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.
20932831 2010 Grb14 inhibits FGF receptor signaling through the regulation of PLC? recruitment and activation.
20889570 2010 Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.
20855522 2011 Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1.
20734064 2010 A large-scale candidate gene association study of age at menarche and age at natural menopause.
20717167 2010 FGF21 signalling pathway and metabolic traits - genetic association analysis.
20686451 2010 Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients.
20672350 2010 Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.
20643727 2010 Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis.
20634891 2010 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
20606682 2010 Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway.
20544801 2010 Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population.
20538960 2010 A candidate gene study of obstructive sleep apnea in European Americans and African Americans.
20536592 2010 Dental agenesis in Kallmann syndrome individuals with FGFR1 mutations.
20422052 2010 A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist.
20421966 2010 Critical role of FLRT1 phosphorylation in the interdependent regulation of FLRT1 function and FGF receptor signalling.
20389169 2010 Decreased expression of FGFR1, SOS1, RAF1 genes in cryptorchidism.
20389085 2010 FGFR1 mutations in Kallmann syndrome.
20388777 2010 Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplification.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20362962 2010 Clinical genetics of Kallmann syndrome.
20179196 2010 FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer.
20139426 2010 A case of Kallmann syndrome carrying a missense mutation in alternatively spliced exon 8A encoding the immunoglobulin-like domain IIIb of fibroblast growth factor receptor 1.
20133753 2010 Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
20117945 2010 Novel insights in FGFR1 regulation: lessons from Kallmann syndrome.
20103604 2010 The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases.
20094046 2010 Fibroblast growth factor signalling: from development to cancer.
20068287 2010 Involvement of alpha-klotho and fibroblast growth factor receptor in the development of secondary hyperparathyroidism.
20036812 2010 Growth factors in tumor microenvironment.
20024612 2010 Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate.
19966287 2010 Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.
19923290 2009 The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis.
19920824 2010 Inhibition of endogenous SPARC enhances pancreatic cancer cell growth: modulation by FGFR1-III isoform expression.
19920251 2009 Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
19890272 2010 Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients.
19822079 Expression of basic fibroblast growth factor, its receptors and syndecans in bladder cancer.
19820032 2009 Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism.
19802384 2009 Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells.
19730683 2009 The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
19728793 2010 Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic development.
19727229 2009 Correlation of the SNPs of FGFR1, FGF10, FGF18 with nonsyndromic cleft lip with or without palate in Chinese population.
19696444 2009 Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.
19666467 2009 Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin.
19665973 2009 The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
19663702 2009 Monoclonal antibodies with selective specificity towards different glycosylation isoforms of FGFR1.
19658100 2009 Phosphorylation of the SSBP2 and ABL proteins by the ZNF198-FGFR1 fusion kinase seen in atypical myeloproliferative disorders as revealed by phosphopeptide-specific MS.
19574212 2009 Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
19489874 2010 Screening of autosomal gene deletions in patients with hypogonadotropic hypogonadism using multiplex ligation-dependent probe amplification: detection of a hemizygosis for the fibroblast growth factor receptor 1.
19458078 2009 Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer.
19453261 2009 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
19330026 2009 Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis.
19261810 2009 Fibroblast growth factor receptor-1 (FGFR1) nuclear dynamics reveal a novel mechanism in transcription control.
19258500 2009 Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival.
19224897 2009 The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations.
19211868 2009 Disruption of fibroblast growth factor receptor signaling in nonmyelinating Schwann cells causes sensory axonal neuropathy and impairment of thermal pain sensitivity.
19096867 2009 Preserved expression of fibroblast growth factor (FGF)-2 and FGF receptor 1 in brain and spinal cord of amyotrophic lateral sclerosis patients.
19082464 2009 Overexpression of the fibroblast growth factor receptor-1 gene correlates with liver metastasis in colorectal cancer.
18978678 2008 Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.
18940940 2009 Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes.
18829480 2008 Immunohistochemical expression of basic fibroblast growth factor and fibroblast growth factor receptors 1 and 2 in the pathogenesis of lung cancer.
18790757 2008 EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line.
18723471 Genetic analysis in patients with Kallmann syndrome: coexistence of mutations in prokineticin receptor 2 and KAL1.
18719360 2008 Temporal-mediated FGFR1 independence: implications for targeting candidate molecules in prostate cancer.
18682503 2008 Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome.
18669637 2008 Effect of FGF-binding protein 3 on vascular permeability.
18665077 2008 Exon III splicing of fibroblast growth factor receptor 1 is modulated by growth factors and cyclin D1.
18593464 2008 Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
18563556 2009 Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors.
18480409 2008 Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis.
18469019 2008 Single nucleotide polymorphisms in new candidate genes are associated with bone mineral density and fracture risk.
18463157 2008 The prevalence of intragenic deletions in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
18441324 2008 Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling.
18415014 2009 Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology.
18412956 2008 Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome.
18411303 2008 Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus.
18315732 2008 Distinct association of genetic variations of vascular endothelial growth factor, transforming growth factor-beta, and fibroblast growth factor receptors with atopy and airway hyperresponsiveness.
18231572 Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.
18216705 2008 FGFR mutations and plagiocephaly.
18171671 2008 Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1.
18160472 2008 Kallmann's syndrome: a comparison of the reproductive phenotypes in men carrying KAL1 and FGFR1/KAL2 mutations.
18059337 2008 High-resolution array CGH analysis of salivary gland tumors reveals fusion and amplification of the FGFR1 and PLAG1 genes in ring chromosomes.
18042549 2008 Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1.
18034870 2008 Diversity in fibroblast growth factor receptor 1 regulation: learning from the investigation of Kallmann syndrome.
17963255 2007 Sequence evaluation of FGF and FGFR gene conserved non-coding elements in non-syndromic cleft lip and palate cases.
17893707 2008 An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia.
17696196 2007 FGFR1 over-expression in primary rhabdomyosarcoma tumors is associated with hypomethylation of a 5' CpG island and abnormal expression of the AKT1, NOG, and BMP4 genes.
17671674 2007 EGFR, HER2 and HER3 expression in esophageal primary tumours and corresponding metastases.
17623664 2007 Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
17545628 2007 Epigenetically controlled fibroblast growth factor receptor 2 signaling imposes on the RAS/BRAF/mitogen-activated protein kinase pathway to modulate thyroid cancer progression.
17414280 2007 Somatic FGFR and TWIST mutations are not a common cause of isolated nonsyndromic single suture craniosynostosis.
17397528 2007 FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis.
17389761 2007 14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.
17366557 2007 A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23.
17360555 2007 Impaired FGF signaling contributes to cleft lip and palate.
17344846 2007 Patterns of somatic mutation in human cancer genomes.
17343269 2007 Isolated sagittal and coronal craniosynostosis associated with TWIST box mutations.
17318851 2007 Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis.
17311277 2007 Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus.
17255109 2007 Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulation.
17154279 2007 Novel FGFR1 sequence variants in Kallmann syndrome, and genetic evidence that the FGFR1c isoform is required in olfactory bulb and palate morphogenesis.
17121884 2006 FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas.
17086194 2006 Klotho converts canonical FGF receptor into a specific receptor for FGF23.
16949906 2007 Basic fibroblast growth factor and fibroblastic growth factor receptor-1 may contribute to head and neck paraganglioma development by an autocrine or paracrine mechanism.
16946300 2006 Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia.
16882753 2006 Novel fibroblast growth factor receptor 1 mutations in patients with congenital hypogonadotropic hypogonadism with and without anosmia.
16876430 2006 Anosmin-1 modulates the FGF-2-dependent migration of oligodendrocyte precursors in the developing optic nerve.
16807244 2006 Heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors.
16807070 2007 Recurrent FGFR1 amplification and high FGFR1 protein expression in oral squamous cell carcinoma (OSCC).
16764984 2006 Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes.
16757108 2006 Paediatric phenotype of Kallmann syndrome due to mutations of fibroblast growth factor receptor 1 (FGFR1).
16685373 2006 siRNA mediated knockdown of fibroblast growth factor receptors 1 or 3 inhibits FGF-induced anchorage-independent clonogenicity but does not affect MAPK activation.
16606836 2006 Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.
16598308 2006 Activation of FGFR1beta signaling pathway promotes survival, migration and resistance to chemotherapy in acute myeloid leukemia cells.
16597617 2006 Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
16507368 2006 Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction.
16481405 2006 Factors controlling fibroblast growth factor receptor-1's cytoplasmic trafficking and its regulation as revealed by FRAP analysis.
16470795 2006 Extended mutational analyses of FGFR1 in osteoglophonic dysplasia.
16424058 2006 Expression of a fibroblast growth factor-binding protein during the development of adenocarcinoma of the pancreas and colon.
16421571 2006 DNA sequence and analysis of human chromosome 8.
16365308 2005 Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
16316338 2005 Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease.
16305343 2005 Alteration on the expression of IL-1, PDGF, TGF-beta, EGF, and FGF receptors and c-Fos and c-Myc proteins in bone marrow mesenchymal stroma cells from advanced untreated lung and breast cancer patients.
16188231 2005 The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells.
16186508 2005 Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas.
16091423 2005 Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors.
15955231 2005 Flt3/Itd mutation is not associated with gastrointestinal stromal tumors (gists).
15929978 2005 Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulation.
15863034 2005 Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations.
15863030 2005 Cellular signaling by fibroblast growth factor receptors.
15845591 2005 Gonadotrophin therapy in Kallmann syndrome caused by heterozygous mutations of the gene for fibroblast growth factor receptor 1: report of three families: case report.
15817662 2005 Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling.
15774903 2005 Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development.
15767480 2005 Acidic fibroblast growth factor (FGF-1) and FGF receptor 1 signaling in human Y79 retinoblastoma.
15695515 2005 Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2.
15680705 2005 Basic fibroblast growth factor and fibroblast growth factor receptor-1 in the human hippocampal formation.
15625620 2005 Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation.
15618886 2005 FGFR1 down-regulation in differentiating human brain and spinal cord neurospheres.
15613419 2005 Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene.
15605412 2005 Kallmann syndrome: 14 novel mutations in KAL1 and FGFR1 (KAL2).
15564375 2004 FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity.
15558020 2005 Reciprocal relationship in gene expression between FGFR1 and FGFR3: implication for tumorigenesis.
15509650 2005 Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15316024 2004 Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.
15297314 2004 Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires alphavbeta3.
15273729 2004 Direct FGF receptor 1 activation through an anti-idiotypic strategy mimicks the biological activity of FGF-2 and inhibits the progression of the bladder carcinoma derived from NBT-II cells.
15117958 2004 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.
15096041 2004 Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly.
15034873 2004 Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome.
15001591 2004 Clinical assessment and mutation analysis of Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, or KAL2) in five families and 18 sporadic patients.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14636241 2003 Fibroblast growth factor receptor-1 interacts with the T-cell receptor signalling pathway.
14587039 2003 Nuclear matrix bound fibroblast growth factor receptor is associated with splicing factor rich and transcriptionally active nuclear speckles.
14513299 2004 Antley-Bixler syndrome with radioulnar synostosis.
12799194 2003 Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin.
12794748 2003 Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain.
12791257 2003 Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP.
12746216 2003 Role and regulation of the fibroblast growth factor axis in human thyroid follicular cells.
12651930 2003 Correlations of the expression of fibroblast growth factor-2, vascular endothelial growth factor, and their receptors with angiogenesis in synovial tissues from patients with internal derangement of the temporomandibular joint.
12627230 2003 Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome.
12614330 2003 cAMP-induced differentiation of human neuronal progenitor cells is mediated by nuclear fibroblast growth factor receptor-1 (FGFR1).
12604616 2003 Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation.
12601080 2003 Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry.
12594223 2003 The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors.
12573278 2003 Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12440521 2002 Selection of peptide ligands binding to fibroblast growth factor receptor 1.
12411316 2002 Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells.
12397010 2002 Enhanced expression of fibroblast growth factors and receptor FGFR-1 during vascular remodeling in chronic obstructive pulmonary disease.
12373339 2002 Immunolocalization of fibroblast growth factor receptors in normal and wounded human skin.
12181353 2002 The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.
12141425 2002 The structure and function of vertebrate fibroblast growth factor receptor 1.
12121226 2002 Costimulation of T cell receptor-triggered IL-2 production by Jurkat T cells via fibroblast growth factor receptor 1 upon its engagement by CD56.
12080186 2002 Noninvasive dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF or FGFR-1 in melanoma cells blocks tumor growth by apoptosis.
12031912 2002 Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.
12020352 2002 A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction.
11877385 2002 FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors.
11759058 2001 Immunohistochemical detection of fibroblast growth factor receptors in normal endocrine cells and related tumors of the digestive system.
11746971 2001 Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL.
11693202 2001 Integrin activation is required for VEGF and FGF receptor protein presence on human microvascular endothelial cells.
11486033 2001 Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis.
11459840 2001 The role of tyrosine residues in fibroblast growth factor receptor 1 signaling in PC12 cells. Systematic site-directed mutagenesis in the endodomain.
11401320 2001 FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines.
11353842 2001 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.
11257130 2001 Importin beta-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation.
11173846 2000 An unusual FGFR1 mutation (fibroblast growth factor receptor 1 mutation) in a girl with non-syndromic trigonocephaly.
11090629 2000 Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors.
11032250 2000 Selection of peptide ligands that bind to acid fibroblast growth factor.
11030354 2000 Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
10950949 2000 Identification of residues important both for primary receptor binding and specificity in fibroblast growth factor-7.
10918587 2000 Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4.
10861678 2000 Clinical findings in a patient with FGFR1 P252R mutation and comparison with the literature.
10830168 2000 Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
10751172 2000 Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures.
10748122 2000 A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2.
10713090 2000 Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner.
10688839 2000 FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33).
10629055 2000 FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.
10579907 1999 Phospholipase C-gamma as a signal-transducing element.
10574949 1999 Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity.
10551883 1999 Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42.
10490103 1999 Structural basis for FGF receptor dimerization and activation.
10464310 1999 Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk.
10454568 1999 Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.
10336501 1999 Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase.
9949182 1999 The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1.
9716603 1998 Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome.
9660748 1998 Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins.
9655399 1998 Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
9632781 1998 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.
9480847 1998 Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells.
9212826 1997 Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues.
9139660 1997 Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
8929854 1996 Distribution of fibroblast growth factor (FGF)-2 and FGF receptor-1 messenger RNA expression and protein presence in the mid-trimester human fetus.
8756477 1996 A natural kinase-deficient variant of fibroblast growth factor receptor 1.
8753773 1996 Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line.
8752212 1996 Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism.
8737680 1996 Nuclear localization of functional FGF receptor 1 in human astrocytes suggests a novel mechanism for growth factor action.
8692946 1996 Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.
8663044 1996 Receptor specificity of the fibroblast growth factor family.
8622701 1996 Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.
8417497 1993 Structural and functional diversity in the FGF receptor multigene family.
8386828 1993 Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5.
8321198 1993 Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
8074689 1994 Distinct role of 2-O-, N-, and 6-O-sulfate groups of heparin in the formation of the ternary complex with basic fibroblast growth factor and soluble FGF receptor-1.
7960240 1994 Expression and functional activity of fibroblast growth factors and their receptors in human pancreatic cancer.
7874169 1994 A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome.
7789168 1995 Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p.
7761103 1995 Fibroblast growth factor receptor-1 regulation of Src family kinases.
7680645 1993 Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor.
7537362 1995 Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.
7520751 1994 Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization.
7516330 1994 Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.
7514169 1994 Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.
2554327 1989 Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).
2167437 1990 Diverse forms of a receptor for acidic and basic fibroblast growth factors.
2162671 1990 The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA.
2159626 1990 Complete sequence of a human receptor for acidic and basic fibroblast growth factors.
1847500 1991 A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes.
1846977 1991 Fibroblast growth factor receptors from liver vary in three structural domains.
1722683 1991 cDNA cloning and expression of a human FGF receptor which binds acidic and basic FGF.
1722570 1991 High-affinity binding and activation of a truncated FGF receptor by both aFGF and bFGF.
1697263 1990 Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
1689310 1990 Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.
1662973 1991 Molecular cloning of a human basic fibroblast growth factor receptor cDNA and expression of a biologically active extracellular domain in a baculovirus system.
1656221 1991 A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.
1652059 1991 The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.
1650441 1991 Alternative splicing generates at least five different isoforms of the human basic-FGF receptor.
1380281 1992 Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues.
1379698 1992 Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis.
1379697 1992 Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis.
1317750 1992 K-sam-related gene, N-sam, encodes fibroblast growth factor receptor and is expressed in T-lymphocytic tumors.