Tbio | Fibroblast growth factor 12 |
Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 47 | 1 | 0.0 | 0.0 |
Hepatomegaly | 285 | 0.0 | 0.0 |
Disease | Target Count | P-value |
---|---|---|
lung carcinoma | 2843 | 1.7e-09 |
malignant mesothelioma | 3232 | 3.0e-06 |
pituitary cancer | 1972 | 2.5e-05 |
medulloblastoma, large-cell | 6241 | 6.7e-05 |
adrenocortical carcinoma | 1428 | 2.0e-04 |
adult high grade glioma | 3801 | 4.0e-04 |
glioblastoma | 5792 | 6.7e-04 |
primitive neuroectodermal tumor | 3035 | 1.5e-03 |
intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.0e-03 |
intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 7.5e-03 |
Pick disease | 1894 | 8.3e-03 |
group 3 medulloblastoma | 4104 | 1.2e-02 |
atypical teratoid / rhabdoid tumor | 5112 | 1.5e-02 |
subependymal giant cell astrocytoma | 2287 | 2.5e-02 |
Astrocytoma, Pilocytic | 3081 | 3.0e-02 |
oligodendroglioma | 2850 | 3.2e-02 |
ependymoma | 4679 | 3.6e-02 |
astrocytic glioma | 2597 | 4.2e-02 |
aldosterone-producing adenoma | 665 | 4.9e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Ebstein anomaly | 16 | 3.253 | 1.6 |
Disease | log2 FC | p |
---|---|---|
adrenocortical carcinoma | -2.038 | 2.0e-04 |
adult high grade glioma | -2.100 | 4.0e-04 |
aldosterone-producing adenoma | -1.228 | 4.9e-02 |
astrocytic glioma | -1.200 | 4.2e-02 |
Astrocytoma, Pilocytic | -1.300 | 3.0e-02 |
atypical teratoid / rhabdoid tumor | -1.600 | 1.5e-02 |
ependymoma | -4.000 | 3.6e-02 |
glioblastoma | -1.800 | 6.7e-04 |
group 3 medulloblastoma | -2.100 | 1.2e-02 |
intraductal papillary-mucinous adenoma (... | -1.200 | 3.0e-03 |
intraductal papillary-mucinous carcinoma... | -1.100 | 7.5e-03 |
lung carcinoma | 1.200 | 1.7e-09 |
malignant mesothelioma | 1.200 | 3.0e-06 |
medulloblastoma, large-cell | -2.400 | 6.7e-05 |
oligodendroglioma | -1.300 | 3.2e-02 |
Pick disease | -1.700 | 8.3e-03 |
pituitary cancer | 1.300 | 2.5e-05 |
primitive neuroectodermal tumor | -2.200 | 1.5e-03 |
subependymal giant cell astrocytoma | -1.650 | 2.5e-02 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG |