| Tdark | F-box only protein 16 |
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 2.4e-28 |
| ulcerative colitis | 1819 | 1.2e-05 |
| Astrocytoma, Pilocytic | 3081 | 3.9e-05 |
| osteosarcoma | 7950 | 1.5e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.7e-04 |
| adult high grade glioma | 3801 | 1.8e-03 |
| active Crohn's disease | 922 | 3.4e-03 |
| astrocytic glioma | 2597 | 1.0e-02 |
| invasive ductal carcinoma | 2951 | 1.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | 1.421 | 3.4e-03 |
| adult high grade glioma | -1.200 | 1.8e-03 |
| astrocytic glioma | -1.400 | 1.0e-02 |
| Astrocytoma, Pilocytic | -1.100 | 3.9e-05 |
| intraductal papillary-mucinous adenoma (... | 1.400 | 1.7e-04 |
| invasive ductal carcinoma | 1.200 | 1.9e-02 |
| lung carcinoma | 3.200 | 2.4e-28 |
| osteosarcoma | -1.466 | 1.5e-04 |
| ulcerative colitis | 1.200 | 1.2e-05 |
MMAFAPPKNTDGPKMQTKMSTWTPLNHQLLNDRVFEERRALLGKWFDKWTDSQRRRILTGLLERCSLSQQ 1 - 70 KFCCRKLQEKIPAEALDFTTKLPRVLSLYIFSFLDPRSLCRCAQVCWHWKNLAELDQLWMLKCLRFNWYI 71 - 140 NFSPTPFEQGIWKKHYIQMVKELHITKPKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNN 141 - 210 SGEKALPPWRSSDKHPTDIIRFNYLDNRDPMETVQQGRRKRNQMTPDFSRQSHDKKNKLQDRTRLRKAQS 211 - 280 MMSRRNPFPLCP 281 - 292 //
