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Tdark Protein FAM69A

This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

 Comments

Property Summary

NCBI Gene PubMed Count 14
PubMed Score 0.61
PubTator Score 1.20

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Cognitive disorder 50 0.0 1.8
Multiple Sclerosis 540 0.0 2.4
Disease Target Count
Diamond-Blackfan Anemia 6 2

Expression

  Differential Expression (25)

Disease log2 FC p
adult high grade glioma -1.400 3.4e-05
atypical teratoid / rhabdoid tumor -1.900 2.3e-04
Chronic Lymphocytic Leukemia 1.028 4.3e-02
cutaneous lupus erythematosus 1.200 6.0e-03
cystic fibrosis -1.106 2.1e-05
ductal carcinoma in situ -1.200 5.3e-03
glioblastoma -1.300 5.9e-06
group 3 medulloblastoma -1.100 5.5e-04
interstitial cystitis 1.300 1.4e-03
intraductal papillary-mucinous adenoma (... 1.500 6.4e-03
intraductal papillary-mucinous carcinoma... 1.300 1.4e-02
intraductal papillary-mucinous neoplasm ... 1.300 4.7e-02
invasive ductal carcinoma -1.700 3.2e-03
malignant mesothelioma -4.700 7.6e-09
medulloblastoma, large-cell -4.100 6.0e-06
non-small cell lung cancer 1.000 3.7e-10
oligodendroglioma -1.500 3.8e-02
ovarian cancer -2.800 4.0e-11
pancreatic cancer 1.100 4.1e-02
pancreatic carcinoma 1.100 4.1e-02
pancreatic ductal adenocarcinoma liver m... -1.701 4.2e-03
pituitary cancer 1.200 2.4e-05
primary Sjogren syndrome 1.100 4.4e-03
primitive neuroectodermal tumor -2.300 1.5e-03
tuberculosis -1.200 2.3e-04

Synonym

Accession Q5T7M9 Q6IRV2
Symbols

Gene

FAM69A

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (9)

 GO Component (2)

 Compartment GO Term (24)

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 MGI Phenotype (1)

 GWAS Trait (5)

 HCA RNA Cell Line (56)

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Gene RIF (4)

AA Sequence 

MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIYVQYSTYTELCRGKDCKKIICDKYKTG      1 - 70
VIDGPACNSLCVTETLYFGKCLSTKPNNQMYLGIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKP     71 - 140
TRGTTVQKFKEMVYSLFKAKLGDQGNLSELVNLILTVADGDKDGQVSLGEAKSAWALLQLNEFLLMVILQ    141 - 210
DKEHTPKLMGFCGDLYVMESVEYTSLYGISLPWVIELFIPSGFRRSMDQLFTPSWPRKAKIAIGLLEFVE    211 - 280
DVFHGPYGNFLMCDTSAKNLGYNDKYDLKMVDMRKIVPETNLKELIKDRHCESDLDCVYGTDCRTSCDQS    281 - 350
TMKCTSEVIQPNLAKACQLLKDYLLRGAPSEIREELEKQLYSCIALKVTANQMEMEHSLILNNLKTLLWK    351 - 420
KISYTNDS                                                                  421 - 428
//

Text Mined References (14)

PMID Year Title