Protein Summary
This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
- ENST00000350210
- ENSP00000307128
- ENSG00000160767
- ENST00000361361
- ENSP00000354958
- ENST00000368368
- ENSP00000357352
- ENST00000572488
- ENSP00000458501
- ENSG00000262666
- ENST00000574749
- ENSP00000460960
- ENST00000575430
- ENSP00000461152
- C1orf2
- COTE1
- COTE1
- C1orf2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 0.85 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.65 | ||
histone modification site profile | 0.59 | ||
tissue sample | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.27 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 75 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.27 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 75 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0