Tbio FAM168A Protein FAM168A

Protein Summary

Description

In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.

Uniprot Accession IDs

• Q92567
• A2ICY2
• A2ID81
• Q86UG2

Gene Name

• FAM168A

Ensembl ID

• ENST00000064778
• ENSP00000064778
• ENSG00000054965
• ENST00000356467
• ENSP00000348852
• ENST00000450446
• ENSP00000390501

Symbol

• KIAA0280
• TCRP1
• TCRP1
• KIAA0280

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.91
kinase perturbation	0.88
histone modification site profile	0.85
virus perturbation	0.68
tissue sample	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.54   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 39   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.54   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0