Property Summary

NCBI Gene PubMed Count 17
PubMed Score 26.90
PubTator Score 12.24

Knowledge Summary


No data available


  Disease (3)

Disease Target Count
Prostatic Neoplasms 471
Disease Target Count P-value
lung adenocarcinoma 2714 5.6e-07
Pick disease 1893 2.5e-05
ovarian cancer 8491 8.3e-05
osteosarcoma 7933 2.2e-03
Disease Target Count Z-score Confidence
Enophthalmos 12 4.437 2.2


  Differential Expression (4)

Disease log2 FC p
osteosarcoma -1.101 2.2e-03
lung adenocarcinoma 1.300 5.6e-07
Pick disease 1.100 2.5e-05
ovarian cancer 1.400 8.3e-05

Gene RIF (8)

24378746 role of UBXD8 in cellular responses to excess fatty acids
23720822 the UAS domain of Ubxd8 mediates it's polymerization upon interaction with long-chain unsaturated fatty acids
23297223 UBXD8-mediated recruitment of p97/VCP to LDs increases lipid droplet (LD) size by inhibiting the activity of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylglycerol hydrolysis.
22454508 Ubx2 and Ubxd8 regulates lipid droplet homeostasis.
22238364 These results indicate that ApoB after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 and UBXD8 are engaged in the predislocation and postdislocation steps, respectively.
21115839 These results suggest that Ubxd8 acts as a brake that limits triglyceride synthesis, and this brake is released when its structure is altered by exposure to unsaturated fatty acids.
20160012 These findings provide evidence for conserved ubiquitination pathways regulating the RasGAP proteins Ira2 (in yeast) and neurofibromin (in humans).
12372427 ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients

AA Sequence

PNPPTLQEAGLSHTEVLFVQDLTDE                                                 421 - 445

Text Mined References (24)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25660456 2015 Identification of ERAD components essential for dislocation of the null Hong Kong variant of ?-1-antitrypsin (NHK).
24378746 2014 Cellular responses to excess fatty acids: focus on ubiquitin regulatory X domain-containing protein 8.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24215460 2014 Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation.
23720822 2013 UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids.
23297223 2013 Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover.
22454508 2012 The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis.
22238364 2012 Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets.
21269460 2011 Initial characterization of the human central proteome.
21115839 2010 Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis.
20160012 2010 The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans.
19818707 2009 The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.
19773358 2009 Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18775313 2008 UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
18711132 2008 SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14741744 2004 Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12372427 2002 Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients.
10048485 1998 Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.