Tchem FABP4 Fatty acid-binding protein, adipocyte

Protein Summary

Description

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15090
• Q6IBA1

Gene Name

• FABP4

Ensembl ID

• ENST00000256104
• ENSP00000256104
• ENSG00000170323

Symbol

• aP2
• ALBP
• AFABP
• A-FABP
• HEL-S-104

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
PubMedID	0.85
small molecule perturbation	0.85
biological process	0.84
transcription factor perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1225.89   (req: < 5)

Gene RIFs: 285   (req: <= 3)

Antibodies: 754   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1225.89   (req: >= 5)

Gene RIFs: 285   (req: > 3)

Antibodies: 754   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 151

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2