Tbio | Fanconi anemia core complex-associated protein 20 |
Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.
Comments
Disease | Target Count | P-value |
---|---|---|
atypical teratoid / rhabdoid tumor | 5112 | 9.0e-09 |
osteosarcoma | 7950 | 3.1e-08 |
pediatric high grade glioma | 1064 | 2.2e-05 |
glioblastoma | 5792 | 1.1e-04 |
ovarian cancer | 8520 | 4.8e-04 |
medulloblastoma, large-cell | 6241 | 2.9e-03 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Aplastic Anemia | 21 | 4.884 | 2.4 |
Disease | log2 FC | p |
---|---|---|
atypical teratoid / rhabdoid tumor | 1.600 | 9.0e-09 |
glioblastoma | 1.200 | 1.1e-04 |
medulloblastoma, large-cell | 1.100 | 2.9e-03 |
osteosarcoma | 1.336 | 3.1e-08 |
ovarian cancer | 1.100 | 4.8e-04 |
pediatric high grade glioma | 1.100 | 2.2e-05 |