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Tbio Fanconi anemia core complex-associated protein 20

Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.

 Comments

Property Summary

NCBI Gene PubMed Count 14
PubMed Score 5.26
PubTator Score 5.17

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Aplastic Anemia 20 4.884 2.4

Expression

  Differential Expression (6)

Disease log2 FC p
atypical teratoid / rhabdoid tumor 1.600 9.0e-09
glioblastoma 1.200 1.1e-04
medulloblastoma, large-cell 1.100 2.9e-03
osteosarcoma 1.336 3.1e-08
ovarian cancer 1.100 4.8e-04
pediatric high grade glioma 1.100 2.2e-05

Synonym

Accession Q6NZ36 A6PW39 A6PW40 A6PW41 A8MQT6 F2Z2L4 Q6ZT64 Q71M24 Q96ND7
Symbols FP7162
C1orf86

Gene

FAAP20

PDB

2MUR   2MUQ   3WWQ  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (13)

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 GO Function (5)

 GO Component (5)

 GO Process (3)

 Compartment GO Term (29)

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 MGI Phenotype (4)

 HCA RNA Cell Line (56)

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Pathway (2)

Protein-protein Interaction (3)

FANCG   FANCA   NT5C  

Gene RIF (6)

AA Sequence 

MEAARRPRLGLSRRRPRPAGGPSGGRPWFLLGGDERERLWAELLRTVSPELILDHEVPSLPAFPGQEPRC      1 - 70
GPEPTEVFTVGPKTFSWTPFPPDLWGPGRSYRLLHGAGGHLESPARSLPQRPAPDPCRAPRVEQQPSVEG     71 - 140
AAALRSCPMCQKEFAPRLTQLDVDSHLAQCLAESTEDVTW                                  141 - 180
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Text Mined References (18)

PMID Year Title