Tbio F8 Coagulation factor VIII

Protein Summary

Description

Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P00451
• Q14286
• Q5HY69

Gene Name

• F8

Ensembl ID

• ENST00000330287
• ENSP00000327895
• ENSG00000185010
• ENST00000360256
• ENSP00000353393

Symbol

• F8C
• AHF
• F8B
• F8C
• HEMA
• FVIII
• DXS1253E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
protein domain	0.99
disease	0.7
cellular component	0.65
interacting protein	0.64

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Coagulation Factor Viii

Protein / Receptor / Coagulation Factor Viii

Protein / Hydrolase / Coagulation Factor Viii

Protein / Cell Adhesion Molecule / Coagulation Factor Viii

DTO Classes

Protein / Enzyme / Hydrolase / Coagulation Factor Viii

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5132.75   (req: < 5)

Gene RIFs: 500   (req: <= 3)

Antibodies: 965   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5132.75   (req: >= 5)

Gene RIFs: 500   (req: > 3)

Antibodies: 965   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0