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Tbio
ERLIN2
Erlin-2

Protein Summary
Description
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618). This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276461
  • ENSP00000276461
  • ENSG00000147475
  • ENST00000335171
  • ENSP00000335220
  • ENST00000397228
  • ENSP00000380405
  • ENST00000518586
  • ENSP00000427847
  • ENST00000519638
  • ENSP00000428112
  • ENST00000523107
  • ENSP00000473292
  • ENST00000523887
  • ENSP00000429903
  • ENST00000648919
  • ENSP00000497100

Symbol
  • C8orf2
  • SPFH2
  • NET32
  • SPFH2
  • SPG18
  • C8orf2
  • Erlin-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.97
transcription factor perturbation
0.96
microRNA
0.91
transcription factor binding site profile
0.84


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.22   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.22   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0