ERF
ETS domain-containing transcription factor ERF
Protein Summary
Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
- ENST00000222329
- ENSP00000222329
- ENSG00000105722
- ENST00000440177
- ENSP00000388173
- PE2
- CRS4
- PE-2
- CHYTS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.84 | ||
ligand (protein) perturbation | 0.83 | ||
transcription factor | 0.68 | ||
transcription factor binding site profile | 0.66 | ||
biological process | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 620.33 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 306 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 620.33 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 306 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0