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Tbio
EPCAM
Epithelial cell adhesion molecule

Protein Summary
Description
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263735
  • ENSP00000263735
  • ENSG00000119888

Symbol
  • GA733-2
  • M1S2
  • M4S1
  • MIC18
  • TACSTD1
  • TROP1
  • ESA
  • KSA
  • M4S1
  • MK-1
  • DIAR5
  • EGP-2
  • EGP40
  • KS1/4
  • MIC18
  • TROP1
  • EGP314
  • HNPCC8
  • TACSTD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.95
transcription factor perturbation
0.84
PubMedID
0.68
gene perturbation
0.67
disease
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3177.68   (req: < 5)
Gene RIFs: 313   (req: <= 3)
Antibodies: 4043   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3177.68   (req: >= 5)
Gene RIFs: 313   (req: > 3)
Antibodies: 4043   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0