Tchem | Histone acetyltransferase p300 |
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Comments
Property Summary
Ligand Count | 25 |
NCBI Gene PubMed Count | 545 |
PubMed Score | 6016.68 |
PubTator Score | 3116.19 |
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8520 | 4.2e-14 |
psoriasis | 6694 | 1.1e-07 |
osteosarcoma | 7950 | 9.3e-05 |
adult high grade glioma | 3801 | 6.4e-03 |
acute myeloid leukemia | 783 | 7.6e-03 |
intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 8.8e-03 |
Rheumatoid arthritis | 1191 | 1.5e-02 |
intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.7e-02 |
Waldenstrons macroglobulinemia | 765 | 2.9e-02 |
X-linked cerebral adrenoleukodystrophy | 116 | 4.4e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Breast cancer | 3578 | 0.0 | 0.5 |
Carcinoma | 11493 | 0.0 | 1.5 |
Endometrial cancer | 311 | 0.0 | 0.6 |
Immune system cancer | 140 | 0.0 | 0.6 |
Kidney cancer | 2613 | 0.0 | 1.0 |
Large intestine cancer | 126 | 0.0 | 0.5 |
Lymphoid leukemia | 160 | 0.0 | 0.6 |
lung cancer | 4740 | 0.0 | 0.5 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Crohn's disease | 321 | 0.0 | 3.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Prostate cancer | 175 | 0.0 | 5.0 |
Disease | log2 FC | p |
---|---|---|
acute myeloid leukemia | 1.200 | 7.6e-03 |
adult high grade glioma | -1.100 | 6.4e-03 |
intraductal papillary-mucinous carcinoma... | 1.100 | 1.7e-02 |
intraductal papillary-mucinous neoplasm ... | 1.200 | 8.8e-03 |
osteosarcoma | -1.764 | 9.3e-05 |
ovarian cancer | -2.200 | 4.2e-14 |
psoriasis | -1.100 | 1.1e-07 |
Rheumatoid arthritis | 1.500 | 1.5e-02 |
Waldenstrons macroglobulinemia | 1.090 | 2.9e-02 |
X-linked cerebral adrenoleukodystrophy | 1.100 | 4.4e-02 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
CHEMBL1797936
pIC50 6.00
CHEMBL3416536
pIC50 6.00
CHEMBL505121
pIC50 6.01
CHEMBL2031566
pIC50 6.18
CHEMBL2030281
pIC50 6.29
CHEMBL1823895
pKd 6.46
CHEMBL1331211
pIC50 6.48
CHEMBL3734823
pIC50 6.50
CHEMBL3416552
pIC50 6.59
CHEMBL3774655
pKd 6.78
CHEMBL3421930
pKd 6.96
CHEMBL3775655
pIC50 7.16
CHEMBL3814752
pIC50 7.29
CHEMBL3622373
pKd 7.50
CHEMBL3774491
pIC50 7.66
CHEMBL3774787
pIC50 7.96
anacardic acid
pIC50 5.30
C646
pKi 6.40
curcumin
pIC50 4.60
epigallocatechin-3-gallate
pIC50 4.52
MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGM 1 - 70 VQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGT 71 - 140 SGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGRGRQNMQYPNP 141 - 210 GMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVL 211 - 280 SNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHK 281 - 350 CQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNA 351 - 420 GDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKN 421 - 490 QQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAA 491 - 560 QPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYY 561 - 630 HLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPN 631 - 700 QMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQF 701 - 770 PSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTP 771 - 840 TPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQP 841 - 910 QQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEA 911 - 980 KMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFK 981 - 1050 PEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDD 1051 - 1120 IWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDAT 1121 - 1190 YYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVL 1191 - 1260 HHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASD 1261 - 1330 KTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDS 1331 - 1400 VHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKM 1401 - 1470 LDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDV 1471 - 1540 TKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLP 1541 - 1610 PIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETR 1611 - 1680 WHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRN 1681 - 1750 ANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQH 1751 - 1820 RLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRT 1821 - 1890 QAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMT 1891 - 1960 PMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQ 1961 - 2030 PGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPI 2031 - 2100 PGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNM 2101 - 2170 NHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMG 2171 - 2240 QIGQLPQALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSP 2241 - 2310 QPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNP 2311 - 2380 GMANLHGASATDLGLSTDNSDLNSNLSQSTLDIH 2381 - 2414 //