Property Summary

NCBI Gene PubMed Count 23
PubMed Score 62.73
PubTator Score 73.34

Knowledge Summary


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Gene RIF (11)

25794010 Results suggest that ENTPD5 affects lung cancer apoptosis via Caspase 3 pathway, and can be potentially used to monitor prognosis or to guide appropriate therapeutic regimens.
25045656 The main point of this review is to integrate the findings and proposed theories about the role played by NTPDase5/mt-PCPH in cancer progression, considering that these proteins have been suggested as potential early diagnostic tools and therapy targets.
23921441 These results strongly suggest that the mt-PCPH ( ENTPD5)oncoprotein may regulate the cellular energy levels and subsequent chemoresistance by an NTPDase-independent mechanism
22992974 Upregulation of ENTPD5 is associated with altered metabolism in gliomablastoma multiforme.
22169232 The elevation of ENTPD5 activity therefore protects AKT-active cancer cells from protein-overloading-induced endoplasmic reticulum stress and the resulting growth arrest and apoptosis.
21074248 Study reports that ENTPD5, an endoplasmic reticulum (ER) enzyme, is upregulated in cell lines and primary human tumor samples with active AKT.
20601676 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
19117992 Findings identify PCPH as an important participant in the chemotherapy response of prostate cancer cells and establish a role for PCPH-PKCalpha-Bcl-2 functional interactions in the drug response process.
18006831 PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism
16465363 Results positively identify PCPH as a good early molecular marker for testicular neoplasms, and strongly indicate that immunodetection of truncated PCPH polypeptides may be a useful diagnostic tool for testicular germ cell tumors.
12489110 deregulation and loss of expression in the progression of laryngeal neoplasia [PCPH]

AA Sequence

LQSLGISH                                                                  421 - 428

Text Mined References (27)

PMID Year Title
25794010 2015 ENTPD5 induces apoptosis in lung cancer cells via regulating caspase 3 expression.
25416956 2014 A proteome-scale map of the human interactome network.
25045656 2014 NTPDase5/PCPH as a new target in highly aggressive tumors: a systematic review.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23921441 2013 The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
22992974 2012 ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme.
22169232 2011 ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells.
21074248 2010 The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.
20601676 2010 Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease.
19159218 2009 Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
19117992 2009 PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Calpha-mediated Bcl-2 stabilization.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
18006831 2007 PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism.
16465363 2006 PCPH expression is an early event in the development of testicular germ cell tumors.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
15698960 2005 Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12508121 2003 The DNA sequence and analysis of human chromosome 14.
12489110 2002 Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11041857 2000 Biochemical characterization of CD39L4.
10708485 2000 The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells.
10400613 1999 CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates.
9676430 1998 The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster.
9271669 1997 Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes.