ENTPD3
Ectonucleoside triphosphate diphosphohydrolase 3
Protein Summary
Has a threefold preference for the hydrolysis of ATP over ADP. This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]
- ENST00000301825
- ENSP00000301825
- ENSG00000168032
- ENST00000445129
- ENSP00000404671
- ENST00000456402
- ENSP00000401565
- CD39L3
- HB6
- CD39L3
- NTPDase-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
histone modification site profile | 0.68 | ||
gene perturbation | 0.55 | ||
disease | 0.52 | ||
microRNA | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.2 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 250 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.2 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 250 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0