Tbio NPRL3 GATOR complex protein NPRL3

Protein Summary

Description

As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. The function of the encoded protein is not known. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q12980
• D3DU40
• Q1W6H0
• Q4TT56
• Q92469

Gene Name

• NPRL3

Ensembl ID

• ENST00000611875
• ENSP00000478273
• ENSG00000103148
• ENST00000620134
• ENSP00000483814

Symbol

• C16orf35
• CGTHBA
• MARE
• MARE
• NPR3
• HS-40
• RMD11
• CGTHBA
• FFEVF3
• C16orf35

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.82
tissue sample	0.77
cell type or tissue	0.76
disease	0.69
phenotype	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.85   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.85   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0