You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DAOA
D-amino acid oxidase activator

Protein Summary
Description
Seems to activate D-amino acid oxidase. This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329625
  • ENSP00000329951
  • ENSG00000182346
  • ENST00000375936
  • ENSP00000365103
  • ENST00000473269
  • ENSP00000470244
  • ENST00000559369
  • ENSP00000453831
  • ENST00000600388
  • ENSP00000472260
  • ENST00000618629
  • ENSP00000483757

Symbol
  • G72
  • LG72
  • SG72
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.74
disease
0.46
phenotype
0.46
cell line
0.44
cellular component
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.24   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.24   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0