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Tbio
CCL4L1
C-C motif chemokine 4-like

Protein Summary
Description
Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5. This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610565
  • ENSP00000484498
  • ENSG00000276070
  • ENST00000613173
  • ENSP00000484455
  • ENST00000613828
  • ENSP00000484322
  • ENSG00000282604
  • ENST00000614182
  • ENSP00000482862
  • ENSG00000276125
  • ENST00000615418
  • ENSP00000483206
  • ENST00000616100
  • ENSP00000484148
  • ENST00000617405
  • ENSP00000483330
  • ENST00000617416
  • ENSP00000480089
  • ENST00000620055
  • ENSP00000481323
  • ENST00000620063
  • ENSP00000478376
  • ENST00000620098
  • ENSP00000479774
  • ENST00000620250
  • ENSP00000483609
  • ENST00000620576
  • ENSP00000479354
  • ENST00000620708
  • ENSP00000479126
  • ENSG00000275313
  • ENST00000620732
  • ENSP00000481969
  • ENST00000622783
  • ENSP00000479833
  • ENST00000631554
  • ENSP00000487911
  • ENST00000631660
  • ENSP00000488687
  • ENST00000631768
  • ENSP00000488094
  • ENST00000631782
  • ENSP00000488541
  • ENST00000631808
  • ENSP00000487651
  • ENST00000632416
  • ENSP00000487859
  • ENST00000632480
  • ENSP00000488369
  • ENST00000632699
  • ENSP00000488366
  • ENST00000632710
  • ENSP00000488758
  • ENST00000633309
  • ENSP00000488719
  • ENST00000633550
  • ENSP00000488736
  • ENST00000633849
  • ENSP00000487792
  • ENST00000633897
  • ENSP00000488897
  • ENST00000633927
  • ENSP00000488430
  • ENST00000634027
  • ENSP00000488439
  • ENST00000634078
  • ENSP00000488231
  • ENST00000634191
  • ENSP00000487715

Symbol
  • CCL4L
  • LAG1
  • SCYA4L1
  • LAG1
  • CCL4L
  • LAG-1
  • SCYA4L
  • AT744.2
  • SCYA4L1
  • SCYA4L2
  • MIP-1-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.85
disease
0.62
tissue
0.47
phenotype
0.46
biological term
0.39


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 537.76   (req: < 5)
View Publications
Gene RIFs: 5   (req: <= 3)
View Gene RIFs
Antibodies: 106   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 537.76   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0