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Tbio
ARFRP1
ADP-ribosylation factor-related protein 1

Protein Summary
Description
Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000607873
  • ENSP00000476756
  • ENSG00000101246
  • ENST00000612157
  • ENSP00000479058
  • ENST00000612256
  • ENSP00000484109
  • ENST00000614942
  • ENSP00000483130
  • ENST00000618568
  • ENSP00000481446
  • ENST00000618838
  • ENSP00000479616
  • ENST00000619493
  • ENSP00000479940
  • ENST00000622789
  • ENSP00000483486

Symbol
  • ARP1
  • ARP
  • Arp1
  • ARL18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
molecular function
0.91
histone modification site profile
0.86
protein domain
0.73
interacting protein
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.43   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.43   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0