You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IFI27
Interferon alpha-inducible protein 27, mitochondrial

Protein Summary
Description
Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the vi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612813
  • ENSP00000483430
  • ENSG00000165949
  • ENST00000612838
  • ENSP00000483932
  • ENSG00000275214
  • ENST00000613997
  • ENSP00000484089
  • ENST00000615978
  • ENSP00000483291
  • ENST00000616764
  • ENSP00000477753
  • ENST00000618863
  • ENSP00000482635
  • ENST00000621160
  • ENSP00000483498
  • ENST00000627111
  • ENSP00000486608

Symbol
  • P27
  • ISG12
  • FAM14D
  • ISG12A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
small molecule perturbation
0.94
gene perturbation
0.83
cellular component
0.7
biological process
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.64   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.64   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0