Tbio RECQL4 ATP-dependent DNA helicase Q4

Protein Summary

Description

DNA-dependent ATPase. May modulate chromosome segregation. The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• O94761
• A0A087WZ30
• Q3Y424
• Q96DW2
• Q96F55

Gene Name

• RECQL4

Ensembl ID

• ENST00000617875
• ENSP00000482313
• ENSG00000160957

Symbol

• RECQ4
• RECQ4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.92
phenotype	0.83
biological term	0.68
tissue sample	0.65

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Atp-dependent Dna Helicase Q4

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Atp-dependent Dna Helicase Q4

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Atp-dependent Dna Helicase Q4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.16   (req: < 5)

Gene RIFs: 89   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.16   (req: >= 5)

Gene RIFs: 89   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0