SOCS7
Suppressor of cytokine signaling 7
Protein Summary
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
- ENST00000612932
- ENSP00000482229
- ENSG00000274211
- ENST00000615473
- ENSP00000480736
- ENSG00000274229
- NAP4
- SOCS6
- NAP4
- NCKAP4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor | 0.72 | ||
hub protein | 0.71 | ||
transcription factor binding site profile | 0.69 | ||
histone modification site profile | 0.62 | ||
cellular component | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 195.55 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 183 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 195.55 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 183 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0