Protein Summary
Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling. This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition. An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]
- ENST00000538115
- ENSP00000445091
- ENSG00000146839
- ENST00000542585
- ENSP00000444427
- ENST00000546213
- ENSP00000441117
- ENST00000546292
- ENSP00000445943
- ENST00000613979
- ENSP00000480750
- ENST00000618565
- ENSP00000478371
- ENST00000620596
- ENSP00000481742
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.99 | ||
gene perturbation | 0.81 | ||
cell line | 0.57 | ||
tissue sample | 0.49 | ||
cellular component | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.23 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.23 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0