Tdark CCDC28A Coiled-coil domain-containing protein 28A

Protein Summary

Description

This gene encodes a coiled-coil domain containing protein. Although the specific function of this gene has not yet been determined, this gene is a known translocation partner of nucleoporin 98 in acute leukemias. The resulting fusion gene produces a nucleoporin 98-coiled-coil domain-containing protein 28A chimeric protein which may be involved in promoting myeloproliferative neoplasms. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• Q8IWP9
• E1P591
• Q32NC7
• Q66K67
• Q96E23
• Q9Y430

Gene Name

• CCDC28A

Ensembl ID

• ENST00000332797
• ENSP00000332716
• ENSG00000024862
• ENST00000611852
• ENSP00000479060

Symbol

• C6orf80
• C6orf80
• CCRL1AP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
histone modification site profile	0.9
virus perturbation	0.9
transcription factor binding site profile	0.7
disease perturbation	0.62

Protein Classes

PANTHER Classes

Protein / Receptor / Coiled-coil Domain-containing Protein 28a

DTO Classes

Protein / Receptor / Coiled-coil Domain-containing Protein 28a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.89   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 132   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.89   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0