Tbio CCL16 C-C motif chemokine 16

Protein Summary

Description

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15467
• Q4KKU0

Gene Name

• CCL16

Ensembl ID

• ENST00000611905
• ENSP00000478024
• ENSG00000275152
• ENST00000621559
• ENSP00000482168
• ENSG00000275095

Symbol

• ILINCK
• NCC4
• SCYA16
• LEC
• LMC
• NCC4
• CKb12
• HCC-4
• LCC-1
• Mtn-1
• NCC-4
• SCYL4
• ILINCK
• SCYA16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.93
cell line	0.61
microRNA	0.58
gene perturbation	0.57
metabolite	0.45

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-c Motif Chemokine 16

DTO Classes

Protein / Signaling / Chemokine / C-c Motif Chemokine 16

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.6   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 459   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.6   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 459   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0