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Tbio
TMPRSS4
Transmembrane protease serine 4

Protein Summary
Description
Probable protease. Seems to be capable of activating ENaC (By similarity). This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000437212
  • ENSP00000416037
  • ENSG00000137648
  • ENST00000522824
  • ENSP00000430547
  • ENST00000523251
  • ENSP00000429209
  • ENST00000534111
  • ENSP00000435184
  • ENST00000618855
  • ENSP00000477949

Symbol
  • TMPRSS3
  • CAPH2
  • MT-SP2
  • TMPRSS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.88
cell type or tissue
0.67
microRNA
0.62
phenotype
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0