Tdark GGTLC3 Putative glutathione hydrolase light chain 3

Protein Summary

Description

Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC3, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]

Uniprot Accession IDs

• B5MD39
• A6NEA2

Gene Name

• GGTLC3

Ensembl ID

• ENST00000619998
• ENSP00000477856
• ENSG00000274252

Symbol

• GGT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.98
cellular component	0.72
cell line	0.71
tissue	0.44
PubMedID	0.17

Protein Classes

PANTHER Classes

Protein / ... / Protease / Putative Glutathione Hydrolase Light Chain 3

DTO Classes

Protein / Enzyme / Protease / Putative Glutathione Hydrolase Light Chain 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.64   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 5   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.64   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0