Tdark ANAPC16 Anaphase-promoting complex subunit 16

Protein Summary

Description

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Uniprot Accession IDs

• Q96DE5
• APC16

Gene Name

• ANAPC16

Ensembl ID

• ENST00000299381
• ENSP00000299381
• ENSG00000166295
• ENST00000621663
• ENSP00000477760

Symbol

• C10orf104
• CENP-27
• MSAG
• APC16
• CENP-27
• C10orf104
• bA570G20.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
disease perturbation	0.87
histone modification site profile	0.86
transcription factor perturbation	0.84
small molecule perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.53   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 13   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.53   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0