Tbio NAP1L1 Nucleosome assembly protein 1-like 1

Protein Summary

Description

Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]

Uniprot Accession IDs

• P55209
• B3KNT8
• B3KV44

Gene Name

• NAP1L1

Ensembl ID

• ENST00000261182
• ENSP00000261182
• ENSG00000187109
• ENST00000393263
• ENSP00000376947
• ENST00000431879
• ENSP00000409795
• ENST00000549596
• ENSP00000447793
• ENST00000618691
• ENSP00000477538

Symbol

• NRP
• NRP
• NAP1
• NAP1L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	1
viral protein	1
virus	1
disease perturbation	0.99

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Phosphatase Inhibitor / Nucleosome Assembly Protein 1-like 1

DTO Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Phosphatase Inhibitor / Nucleosome Assembly Protein 1-like 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.3   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.3   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0