Tbio DGKK Diacylglycerol kinase kappa

Protein Summary

Description

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q5KSL6
• B2RP91
• DAG kinase kappa

Gene Name

• DGKK

Ensembl ID

• ENST00000611977
• ENSP00000477515
• ENSG00000274588

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
protein domain	0.85
metabolite	0.83
gene perturbation	0.74
interacting protein	0.7

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Diacylglycerol Kinase Kappa

DTO Classes

Protein / Enzyme / Transferase / Diacylglycerol Kinase Kappa

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.4   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.4   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0