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Tbio
PPP1R12B
Protein phosphatase 1 regulatory subunit 12B

Protein Summary
Description
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290419
  • ENSP00000484005
  • ENSG00000077157
  • ENST00000356764
  • ENSP00000349206
  • ENST00000391959
  • ENSP00000375821
  • ENST00000480184
  • ENSP00000417159
  • ENST00000491336
  • ENSP00000480852
  • ENST00000608999
  • ENSP00000476755

Symbol
  • MYPT2
  • MYPT2
  • PP1bp55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.83
transcription factor binding site profile
0.78
co-expressed gene
0.76
virus perturbation
0.64
phenotype
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.12   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.12   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0