Tdark UGT2A1 UDP-glucuronosyltransferase 2A1

Protein Summary

Description

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium. The protein encoded by this gene belongs to the UDP-glycosyltransferase family, members of which catalyze biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q9Y4X1
• B4E2F4
• D3GER1
• D3GER2
• E9PDM7
• J3KNA3
• UDPGT 2A1

Gene Name

• UGT2A1

Ensembl ID

• ENST00000286604
• ENSP00000286604
• ENSG00000173610
• ENST00000457664
• ENSP00000387888
• ENST00000503640
• ENSP00000424478
• ENST00000604021
• ENSP00000474383
• ENSG00000271271
• ENST00000604629
• ENSP00000475028

Symbol

• UGT2A2
• UDPGT2A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.61
pathway	0.52
tissue	0.48
microRNA	0.47
biological term	0.34

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.87   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 12   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.87   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0