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Tbio
TAF15
TATA-binding protein-associated factor 2N

Protein Summary
Description
RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000604841
  • ENSP00000474609
  • ENSG00000270647
  • ENST00000605844
  • ENSP00000474096
  • ENST00000617382
  • ENSP00000480040
  • ENSG00000276833
  • ENST00000631482
  • ENSP00000488684

Symbol
  • RBP56
  • TAF2N
  • Npl3
  • RBP56
  • TAF2N
  • TAFII68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor binding site profile
0.9
gene perturbation
0.74
tissue
0.73
histone modification site profile
0.72


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.45   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.45   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0