You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SNRNP70
U1 small nuclear ribonucleoprotein 70 kDa

Protein Summary
Description
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158). Isoform 3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221448
  • ENSP00000221448
  • ENSG00000104852
  • ENST00000401730
  • ENSP00000385077
  • ENST00000595231
  • ENSP00000471006
  • ENST00000598441
  • ENSP00000472998
  • ENST00000601065
  • ENSP00000468952

Symbol
  • RNPU1Z
  • RPU1
  • SNRP70
  • U1AP1
  • RPU1
  • Snp1
  • U1AP
  • U170K
  • U1RNP
  • RNPU1Z
  • SNRP70
  • U1-70K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.97
kinase perturbation
0.97
ligand (protein) perturbation
0.96
transcription factor binding site profile
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 956.46   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 956.46   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0