Tbio IL12RB1 Interleukin-12 receptor subunit beta-1

Protein Summary

Description

Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• P42701
• A8K308
• B2RPF1
• B7ZKK3
• Q8N6Q7
• IL-12 receptor subunit beta-1

Gene Name

• IL12RB1

Ensembl ID

• ENST00000322153
• ENSP00000314425
• ENSG00000096996
• ENST00000593993
• ENSP00000472165
• ENST00000600835
• ENSP00000470788

Symbol

• IL12R
• IL12RB
• CD212
• IMD30
• IL12RB
• IL-12R-BETA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.89
tissue sample	0.73
disease	0.66
cell type or tissue	0.63
tissue	0.61

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Interleukin-12 Receptor Subunit Beta-1

Protein / Defense/immunity Protein / Interleukin-12 Receptor Subunit Beta-1

DTO Classes

Protein / Signaling / Cytokine / Interleukin-12 Receptor Subunit Beta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.6   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 432   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.6   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 432   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0