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Tbio
MYL6
Myosin light polypeptide 6

Protein Summary
Description
Regulatory light chain of myosin. Does not bind calcium. Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000547649
  • ENSP00000446714
  • ENSG00000092841
  • ENST00000548293
  • ENSP00000448101
  • ENST00000550697
  • ENSP00000446955

Symbol
  • LC17
  • ESMLC
  • LC17A
  • LC17B
  • MLC-3
  • MLC1SM
  • MLC3NM
  • MLC3SM
  • LC17-GI
  • LC17-NM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.98
hub protein
0.96
transcription factor perturbation
0.88
transcription factor binding site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.77   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.77   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0