Tbio SLCO1C1 Solute carrier organic anion transporter family member 1C1

Protein Summary

Description

Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity). This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q9NYB5
• B7Z251
• B7Z3Q3
• B7Z8P1
• F5GZD6
• Q5JPA4

Gene Name

• SLCO1C1

Ensembl ID

• ENST00000266509
• ENSP00000266509
• ENSG00000139155
• ENST00000540354
• ENSP00000438665
• ENST00000545102
• ENSP00000444527
• ENST00000545604
• ENSP00000444149

Symbol

• OATP14
• OATP1C1
• OATPF
• SLC21A14
• OATP1
• OATPF
• OATP-F
• OATP14
• OATP1C1
• OATPRP5
• SLC21A14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	0.72
cell line	0.68
cell type or tissue	0.59
tissue	0.54
disease	0.49

Protein Classes

PANTHER Classes

Protein / Transporter / Solute Carrier Organic Anion Transporter Family Member 1c1

Protein / ... / Protease Inhibitor / Solute Carrier Organic Anion Transporter Family Member 1c1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slco Family Of Organic Anion Transporting Polypeptides / Solute Carrier Organic Anion Transporter Family Member 1c1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.26   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.26   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0