Tbio CPEB2 Cytoplasmic polyadenylation element-binding protein 2

Protein Summary

Description

May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q7Z5Q1
• E7EPM3
• F5H160
• Q3B8N6
• Q3MI89
• Q3MI90
• Q3MI92
• Q7Z5Q0
• CPE-BP2

Gene Name

• CPEB2

Ensembl ID

• ENST00000345451
• ENSP00000334058
• ENSG00000137449
• ENST00000382395
• ENSP00000371832
• ENST00000382401
• ENSP00000371838
• ENST00000442003
• ENSP00000414270
• ENST00000507071
• ENSP00000424084
• ENST00000538197
• ENSP00000443985
• ENST00000634696
• ENSP00000488925
• ENSG00000283087
• ENST00000634867
• ENSP00000489160
• ENST00000635061
• ENSP00000489427
• ENST00000635093
• ENSP00000489406
• ENST00000635362
• ENSP00000489336
• ENST00000635651
• ENSP00000489362

Symbol

• CPEB-2
• CPE-BP2
• hCPEB-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
transcription factor binding site profile	0.91
transcription factor perturbation	0.8
PubMedID	0.76
tissue sample	0.69

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Polyadenylation Factor / Cytoplasmic Polyadenylation Element-binding Protein 2

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Polyadenylation Factor / Cytoplasmic Polyadenylation Element-binding Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.08   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.08   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0