REEP1
Receptor expression-enhancing protein 1
Protein Summary
Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (PubMed:20200447). May play a role in long-term axonal maintenance (PubMed:24478229). This gene encodes a mitochondrial protein that functions to enhance the cell surface expression of odorant receptors. Mutations in this gene cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
- ENST00000165698
- ENSP00000165698
- ENSG00000068615
- ENST00000453231
- ENSP00000392197
- ENST00000535845
- ENSP00000437567
- ENST00000541910
- ENSP00000442681
- C2orf23
- SPG31
- HMN5B
- SPG31
- Yip2a
- C2orf23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.84 | ||
transcription factor perturbation | 0.8 | ||
cellular component | 0.71 | ||
small molecule perturbation | 0.67 | ||
microRNA | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.38 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 195 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.38 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 195 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0