Tbio RNF170 E3 ubiquitin-protein ligase RNF170

Protein Summary

Description

E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• Q96K19
• D3DSY6
• E9PIL4
• Q7Z483
• Q86YC0
• Q8IXR7
• Q8N2B5
• Q8N5G9
• Q8NG30
• Q9H0V6

Gene Name

• RNF170

Ensembl ID

• ENST00000240159
• ENSP00000240159
• ENSG00000120925
• ENST00000319073
• ENSP00000325969
• ENST00000319104
• ENSP00000326138
• ENST00000526349
• ENSP00000435782
• ENST00000527424
• ENSP00000434797
• ENST00000534961
• ENSP00000445725

Symbol

• ADSA
• SNAX1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
microRNA	0.74
histone modification site profile	0.73
protein domain	0.73
tissue	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.33   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 112   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.33   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0