Tbio TP53AIP1 p53-regulated apoptosis-inducing protein 1

Protein Summary

Description

May play an important role in mediating p53/TP53-dependent apoptosis. This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q9HCN2
• Q6NT40
• Q7Z6F7
• Q9HCN0
• Q9HCN1
• p53AIP1

Gene Name

• TP53AIP1

Ensembl ID

• ENST00000458238
• ENSP00000390694
• ENSG00000120471
• ENST00000527504
• ENSP00000435175
• ENST00000530777
• ENSP00000432908
• ENST00000531399
• ENSP00000432743
• ENST00000602346
• ENSP00000473353

Symbol

• P53AIP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.74
cell line	0.46
cellular component	0.43
chemical	0.43
biological term	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.24   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.24   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0