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Tchem
DDR1
Epithelial discoidin domain-containing receptor 1

Protein Summary
Description
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259875
  • ENSP00000259875
  • ENSG00000137332
  • ENST00000324771
  • ENSP00000318217
  • ENSG00000204580
  • ENST00000376567
  • ENSP00000365751
  • ENST00000376568
  • ENSP00000365752
  • ENST00000376569
  • ENSP00000365753
  • ENST00000376570
  • ENSP00000365754
  • ENST00000376575
  • ENSP00000365759
  • ENST00000383377
  • ENSP00000372868
  • ENST00000400410
  • ENSP00000383261
  • ENST00000400411
  • ENSP00000383262
  • ENST00000400414
  • ENSP00000383265
  • ENST00000400486
  • ENSP00000383334
  • ENSG00000215522
  • ENST00000400488
  • ENSP00000383336
  • ENST00000400489
  • ENSP00000383337
  • ENST00000400491
  • ENSP00000383338
  • ENST00000400492
  • ENSP00000383339
  • ENST00000412329
  • ENSP00000391805
  • ENSG00000230456
  • ENST00000415092
  • ENSP00000405540
  • ENST00000418800
  • ENSP00000407699
  • ENST00000419412
  • ENSP00000416183
  • ENSG00000234078
  • ENST00000421229
  • ENSP00000415730
  • ENST00000427053
  • ENSP00000416145
  • ENST00000429699
  • ENSP00000401397
  • ENST00000430933
  • ENSP00000397769
  • ENST00000449518
  • ENSP00000414285
  • ENST00000452441
  • ENSP00000405039
  • ENST00000453510
  • ENSP00000401208
  • ENST00000454612
  • ENSP00000406091
  • ENST00000454774
  • ENSP00000400393
  • ENST00000482873
  • ENSP00000421978
  • ENST00000508312
  • ENSP00000422442
  • ENST00000513240
  • ENSP00000427552
  • ENST00000548133
  • ENSP00000449611
  • ENST00000548962
  • ENSP00000448115
  • ENST00000549026
  • ENSP00000449238
  • ENST00000550384
  • ENSP00000447474
  • ENST00000550395
  • ENSP00000449255
  • ENST00000552068
  • ENSP00000449190
  • ENST00000552721
  • ENSP00000449307
  • ENST00000553015
  • ENSP00000448377
  • ENST00000617572
  • ENSP00000479195
  • ENST00000618059
  • ENSP00000479204
  • ENST00000620318
  • ENSP00000484588
  • ENST00000621544
  • ENSP00000484013

Symbol
  • CAK
  • EDDR1
  • NEP
  • NTRK4
  • PTK3A
  • RTK6
  • TRKE
  • CAK
  • DDR
  • NEP
  • HGK2
  • PTK3
  • RTK6
  • TRKE
  • CD167
  • EDDR1
  • MCK10
  • NTRK4
  • PTK3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.99
transcription factor perturbation
0.96
disease perturbation
0.93
PubMedID
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.43   (req: < 5)
Gene RIFs: 158   (req: <= 3)
Antibodies: 706   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.43   (req: >= 5)
Gene RIFs: 158   (req: > 3)
Antibodies: 706   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 100
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10