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Tbio
SMIM20
Small integral membrane protein 20

Protein Summary
Description
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C. Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000506197
  • ENSP00000427407
  • ENSG00000250317
  • ENST00000614775
  • ENSP00000483831

Symbol
  • C4orf52
  • MITRAC7
  • PNX
  • C4orf52
  • MITRAC7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
kinase perturbation
0.6
transcription factor perturbation
0.54
cell type or tissue
0.53
tissue sample
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.19   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 10   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.19   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0